Volumetric magnetic resonance imaging analysis in patients with short-term remission of Cushing's disease
Volumetric magnetic resonance imaging analysis in patients with short-term remission of Cushing's disease
复制标题
库欣病短期缓解患者的体积磁共振成像分析
DOI：
10.1111/cen.13381
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发表时间：
2017-10-01
影响因子：
3.2
通讯作者：
Sun, Qing-Fang
中科院分区：
文献类型：
--
作者：
Jiang, Hong;Ren, Jie;Sun, Qing-Fang
库欣病（CD）短期缓解患者的数据可能提供以前长期缓解研究无法提供的信息。我们的目的是调查在这些患者的大脑结构的变化，并检查这些变化是否与临床feature.DesignA横断面研究进行了performed. MethodsThird-four CD患者（14 CD在短期缓解和20与活跃的CD）和34对照组匹配的年龄，性别和教育进行了临床评估和磁共振成像脑扫描。收集生物统计学测量、疾病持续时间和缓解持续时间数据。在全脑灰质体积进行了检查，使用基于体素的形态测量（VBM）。结果没有差异，观察缓解CD患者和健康对照组之间的内侧额回（MFG）和小脑的灰质体积，而活动性CD患者有较小的灰质体积在这两个区域相比，对照组和缓解CD患者。此外，CD短期缓解患者的缓解时间与这些区域的灰质值之间存在显著相关性。此外，更大的灰质体积在短期缓解患者CD的双边尾状核observed.ConclusionsTrends结构恢复CD患者短期缓解。这一发现与根治性手术后的天数和患者的当前年龄有关。这项研究增强了我们对CD患者皮质醇增多症消退后潜在可逆性的理解。
ObjectiveThe data on patients with short-term remission of Cushing's disease (CD) might provide information that is not available from previous long-term remission studies. We aimed to investigate structural changes in the brain in these patients and to examine whether these changes were associated with clinical characteristics.DesignA cross-sectional study was performed.MethodsThirty-four patients with CD (14 with CD in short-term remission and 20 with active CD) and 34 controls matched for age, sex and education underwent clinical evaluation and magnetic resonance imaging brain scans. Biometric measurements, disease duration and remission duration data were collected. Grey matter volumes in the whole brain were examined using voxel-based morphometry (VBM).ResultsNo differences were observed in the grey matter volumes of the medial frontal gyrus (MFG) and cerebellum between the patients with remitted CD and healthy controls, whereas patients with active CD had smaller grey matter volumes in these two regions compared with controls and patients with remitted CD. Furthermore, significant correlations were found between remission time and grey matter values in these regions in short-term remission patients with CD. Additionally, greater grey matter volumes in the bilateral caudate of short-term remission patients with CD were observed.ConclusionsTrends for structural restoration were found in CD patients with short-term remission. This finding was associated with the number of days elapsed since curative surgery and the current age of the patients. This study enhances our understanding of potential reversibility after the resolution of hypercortisolism in CD patients.