The INSPIRE study: RSV infection during infancy - Authors' reply.
The INSPIRE study: RSV infection during infancy - Authors' reply.
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INSPIRE 研究：婴儿期 RSV 感染 - 作者回复。
DOI：
10.1016/s0140-6736(23)02285-7
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Hartert,TinaV
中科院分区：
文献类型：
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作者：
Rosas-Salazar,Christian;Gebretsadik,Tebeb;Dupont,WilliamD;Hartert,TinaV
Christian Rosas-Salazar及其同事的INSPIRE研究1检查了婴儿期呼吸道合胞病毒（RSV）感染的缺乏与儿童哮喘风险降低之间的关系。为了确保在第一个RSV季节的暴露，该研究专门招募了2012年和2013年6月至12月出生的儿童。2然而，婴儿RSV感染的鉴定基于两种方法：有目的地采集鼻洗液样本（38%）用于疑似急性呼吸道感染，或在1岁时进行血液血清学检测（62%）。这些用于确定RSV感染的方法不足以证明仅招募6月至12月出生的儿童是合理的。我们担心，这种方法可能只是为了增加研究参与者中RSV感染儿童的比例，以进行比较。此外，入组受试者中报告的RSV感染百分比可能被高估为52%，约为另一项研究报告值的三倍。如果不对1月至5月出生的儿童进行敏感性分析，Rosas-Salazar及其同事的研究结果只能代表6月至12月出生的儿童。此外，两组（即婴儿期无RSV感染的儿童和婴儿期有RSV感染的儿童）在以下协变量方面存在显著差异：入组时的年龄（51天vs 60天）、剖腹产分娩方式（29% vs 34%）和存在另一名幼儿
The INSPIRE study by Christian Rosas-Salazar and colleagues1 examines the association between the absence of respiratory syncytial virus (RSV) infection in infancy and the reduced risk of childhood asthma. To ensure exposure during the first RSV season, the study specifically recruited children born between June and December in 2012 and 2013. 2 However, the identification of RSV infection in infants was based on two methods: purposeful sampling of nasal wash (38%) for suspected acute respiratory tract infection, or a blood serology test conducted at age 1 year (62%). These methods employed to determine RSV infection do not sufficiently justify the exclusive enrolment of children born between June and December. We are concerned that this approach could have been employed merely to increase the proportion of children with RSV infection among the study participants for comparative purposes. Moreover, the reported percentage of RSV infection among the enrolled participants was likely to be overestimated at 52%, approximately three times higher than a reported value in another study. 3 Without conducting a sensitivity analysis for children born between January and May, the findings of Rosas-Salazar and colleagues’ study can only be considered representative of children born between June and December. Furthermore, the two groups (ie, children with no RSV infection during infancy, and children with RSV infection during infancy) showed substantial differences in the following covariates: age at enrolment (51 days vs 60 days), mode of birth by caesarean section (29% vs 34%), and presence of another young child