Structure-based modeling of protein: DNA specificity.
Structure-based modeling of protein: DNA specificity.
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DOI：
10.1093/bfgp/elu044
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发表时间：
2015
影响因子：
4
通讯作者：
Adam P. Joyce;Chi Zhang;P. Bradley;J. Havranek
中科院分区：
文献类型：
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作者：
Adam P. Joyce;Chi Zhang;P. Bradley;J. Havranek
蛋白质：DNA 相互作用对于维持和表达基因组中编码的信息的一系列过程至关重要。结构建模是一种旨在在物理化学水平上理解这些相互作用的方法。有人提出，结构建模可以使人们更深入地了解蛋白质：DNA 相互作用的机制，并且该领域的进展不仅有助于合理化观察到的 DNA 结合蛋白的特异性，而且还使研究人员能够设计新的 DNA 位点特异性。在这篇综述中，我们讨论了蛋白质结构描述的最新进展：DNA 相互作用和特异性，以及该领域未来面临的挑战。
Protein:DNA interactions are essential to a range of processes that maintain and express the information encoded in the genome. Structural modeling is an approach that aims to understand these interactions at the physicochemical level. It has been proposed that structural modeling can lead to deeper understanding of the mechanisms of protein:DNA interactions, and that progress in this field can not only help to rationalize the observed specificities of DNA-binding proteins but also to allow researchers to engineer novel DNA site specificities. In this review we discuss recent developments in the structural description of protein:DNA interactions and specificity, as well as the challenges facing the field in the future.