Risk factors and mechanisms of non-alcoholic steatohepatitis.
Risk factors and mechanisms of non-alcoholic steatohepatitis.
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DOI：
10.1016/j.pathophys.2008.04.003
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发表时间：
2008-08-01
期刊：
影响因子：
--
通讯作者：
Rivera, Chantal A
中科院分区：
文献类型：
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作者：
Rivera, Chantal A
十多年来，全球超重和肥胖者的比例每年都在增加。沿着肥胖率的增加，2型糖尿病、心血管疾病和肝病等共病的发病率也在增加。与肥胖相关的肝脏疾病形式被称为非酒精性脂肪性肝炎（NASH），这是由于与慢性酗酒者肝脏的组织学相似性。NASH在成人和儿童人群中均有发生，但其病因尚不清楚。本文综述了NASH的一些常见危险因素，并介绍了提出的疾病发病机制的分子机制。
The worldwide proportion of overweight and obese individuals has increased yearly for more than a decade. Along with rates of obesity, the incidence of co-morbid conditions such as type 2 diabetes, cardiovascular disease and liver disease has also increased. The form of liver disease associated with obesity is termed non-alcoholic steatohepatitis (NASH) due to the histological similarities to livers of chronic alcoholics. NASH has been observed in adult as well as pediatric populations; however, the etiology of this disease is still unknown. This review outlines some of the risk factors commonly associated with NASH and describes molecular mechanisms proposed to underlie disease pathogenesis.