Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease
Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease
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DOI：
10.1111/j.1600-0765.2009.01209.x
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发表时间：
2010-02-01
影响因子：
3.5
通讯作者：
Yamazaki, K.
中科院分区：
文献类型：
--
作者：
Nakajima, T.;Honda, T.;Yamazaki, K.
背景和目的：虽然牙周感染导致的高敏C反应蛋白（hs-CRP）浓度升高可能会增加患冠心病（CHD）的风险，但在健康的日本人群中，牙周感染对hs-CRP水平的影响尚未报道。本研究的目的是在更大范围内证实我们先前的初步研究结果，即慢性牙周炎和随后的牙周治疗都会改变血清C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的水平材料和方法：检测78例牙周炎患者基线和再评估时血清hs-CRP、IL-6和TNF-α的浓度，结果：牙周炎患者血清中hs-CRP和IL-6浓度均显著高于对照组（P < 0. 05），牙周炎患者血清中hs-CRP和IL-6浓度显著高于对照组（P < 0. 05）。相比之下，牙周炎患者的TNF-α浓度明显低于对照组。牙周治疗降低了血清hs-CRP和IL-6的水平，但对TNF-α没有这种影响。当患者根据其hs-CRP的初始浓度分为四组时，只有最高四分位数组的CRP和IL-6浓度在牙周治疗后显着降低。没有显着差异的初始临床参数中观察到的任何quarttile.Conclusion：虽然牙周感染确实影响血清中的hs-CRP和IL-6的浓度，一个亚组的患者存在谁是高度敏感的冠心病与牙周炎相关的风险增加，这表明，可能有受试者有独立的牙周组织破坏本身的易感性冠心病的风险升高。
Background and Objective: Although an elevation in the concentration of high-sensitivity C-reactive protein (hs-CRP) as a result of periodontal infection may account for an increased risk of developing coronary heart disease (CHD), the effect of periodontal infection on the level of hs-CRP in an otherwise healthy Japanese population has not yet been reported. The aim of the present study was to confirm, on a larger scale, our previous pilot study findings that both chronic periodontitis and subsequent periodontal treatment alter the serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).Material and Methods: The concentrations of serum hs-CRP, IL-6 and TNF-alpha were measured in 78 periodontitis patients at baseline and at re-assessment, and in 40 periodontally healthy subjects at the time of examination.Results: The concentrations of hs-CRP and IL-6 in the sera of periodontitis patients were significantly higher than those in control subjects. By contrast, the concentration of TNF-alpha was significantly lower in periodontitis patients than in control subjects. Whereas periodontal treatment decreased the levels of serum hs-CRP and IL-6, no such effect was observed for TNF-alpha. When the patients were subdivided into four groups according to their initial concentration of hs-CRP, only the CRP and IL-6 concentrations of the highest quartile group showed a significant reduction following periodontal treatment. No significant difference in the initial clinical parameters was observed in any quartile.Conclusion: Although periodontal infection does affect the concentration of hs-CRP and IL-6 in serum, a subgroup of patients exist who are highly susceptible to an increased risk of CHD associated with periodontitis, suggesting that there may be subjects who have an elevated risk of CHD independent of susceptibility to periodontal tissue destruction per se.