Clinical Significance of Choroidal Thickness in Eyes with Ocular Ischemic Syndrome.
Clinical Significance of Choroidal Thickness in Eyes with Ocular Ischemic Syndrome.
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DOI：
10.3341/kjo.2021.0155
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发表时间：
2022-03
影响因子：
--
通讯作者：
Kang KT
中科院分区：
文献类型：
--
作者：
Kwon DH;Kim YC;Kang KT
确定脉络膜厚度的临床意义，并评估眼缺血综合征（OIS）患者脉络膜厚度随时间的变化。回顾性分析了2017年11月至2019年8月期间诊断为OIS的16例患者的病历。在早期治疗糖尿病视网膜病变研究网格的每九个区域中，我们比较了OIS眼和未受影响眼之间脉络膜厚度的差异，以及OIS眼在随访期间使用扫频光源光学相干断层扫描的变化。我们分析了最佳矫正视力、眼压、荧光素血管造影（FAG）参数、全身疾病和症状持续时间。研究了FAG参数与OIS眼和未受影响眼的脉络膜厚度比值之间的相关性，以及随访期间OIS眼脉络膜厚度的变化。受试者的中位年龄为67.5岁。在OIS眼中，所有FAG参数在初始检查时均延迟。最佳矫正视力和眼压在OIS和未受影响的眼睛之间有显著差异。虽然在OIS眼睛的早期治疗糖尿病视网膜病变研究的每九个区域中的脉络膜厚度小于未受影响的眼睛，但内颞区、外鼻区和外颞区的脉络膜厚度显示出统计学显著差异。在随访期间，OIS眼的脉络膜厚度变化以及FAG参数与OIS眼和未受影响眼之间的脉络膜厚度值比之间的相关性未被发现具有统计学显著性。OIS眼的脉络膜厚度明显小于未受影响的眼。我们推断脉络膜变薄发生在疾病的早期阶段，因为在随访期间脉络膜厚度的变化并不显著。
To determine the clinical significance of choroidal thickness and evaluate changes in choroidal thickness over time in eyes affected by ocular ischemic syndrome (OIS). Medical records of 16 patients diagnosed with OIS between November 2017 and August 2019 were retrospectively reviewed. In every nine areas of the Early Treatment Diabetic Retinopathy Study grid, we compared the differences in choroidal thickness between the eyes with OIS and unaffected eyes, and its change in the OIS eyes during the follow-up period using swept-source optical coherence tomography. We analyzed the best-corrected visual acuity, intraocular pressure, fluorescein angiography (FAG) parameters, systemic diseases, and the duration of symptoms. Correlation between FAG parameters and the choroidal thickness value ratio in the OIS eyes and the unaffected eyes, and changes in the choroidal thickness in the OIS eyes during follow-up were investigated. Median age of the subjects was 67.5 years. In the OIS eyes, all FAG parameters were delayed at the initial examination. Best-corrected visual acuity and intraocular pressure were significantly different between the OIS and unaffected eyes. While the choroidal thickness in every nine areas of Early Treatment Diabetic Retinopathy Study in the OIS eyes was lesser than the unaffected eyes, the choroidal thickness of inner temporal, outer nasal, and outer temporal area showed statistically significant difference. During follow-up, changes in choroidal thickness of OIS eyes as well as correlation between the FAG parameters and the choroidal thickness value ratio between the OIS eyes and the unaffected eyes were not found to be statistically significant. The choroidal thickness of the eyes with OIS was significantly less compared with the unaffected eyes. We inferred that choroidal thinning takes place in the early phase of the disease as the changes in choroidal thickness during the follow-up period were not significant.