CXCL10/CXCR3 axis is associated with disease activity and the development of mucocutaneous lesions in patients with Behçet's disease.
CXCL10/CXCR3 axis is associated with disease activity and the development of mucocutaneous lesions in patients with Behçet's disease.
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DOI：
10.1038/s41598-017-15189-9
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发表时间：
2017-11-07
影响因子：
4.6
通讯作者：
Song YW
中科院分区：
文献类型：
--
作者：
Lee SJ;Kang SE;Kang EH;Choi BY;Masek-Hammerman K;Syed J;Zhan Y;Neff-Phillips K;Park JK;Lee EY;Lee EB;Song YW
本研究的目的是调查白塞病 (BD) 患者的 CXC 趋化因子及其受体及其与疾病活动性的关系。血液样本采集自 109 名 BD 患者和 36 名年龄和性别匹配的健康对照 (HC)。 BD 患者采集了 22 份随访血样。检测血清CXC趋化因子（CXCL1、CXCL8、CXCL9、CXCL10、CXCL12、CXCL13和CXCL16）和外周血单核细胞（PBMC）中的细胞表面标志物表达（CD3、CD4和CXCR3）。在采血时评估包括疾病活动度在内的临床特征。通过免疫组织化学评估 BD 患者和 HC 皮肤和肠道病变中 CXCR3 的表达。血清 CXCL10 水平与白塞氏病当前活动表 (BDCAF) 的疾病活动度相关 (p<0.001)。在随访的 BD 患者中，血清 CXCL10 水平的变化往往与 BDCAF 的变化相关。 BD患者PBMC中CD3阳性细胞中CXCR3表达的百分比与血清CXCL10水平呈负相关（p = 0.022）。免疫组化显示，BD患者皮肤和肠道病变中CXCR3阳性单核细胞数量高于HC患者。这些结果表明CXCL10/CXCR3轴可能有助于BD的发病机制。
The objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet’s disease (BD) and their associations with disease activity. Blood samples were collected from 109 BD patients and 36 age- and sex-matched healthy controls (HCs). Twenty-two follow-up blood samples were collected in BD patients. Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) and cell surface marker expression (CD3, CD4 and CXCR3) in peripheral blood mononuclear cells (PBMCs) were assayed. Clinical features including disease activity were evaluated at the time of blood collection. CXCR3 expression in skin and intestinal lesions from BD patients and HCs was assessed via immunohistochemistry. Serum CXCL10 levels were correlated with disease activity in terms of Behçet’s Disease Current Activity Form (BDCAF) (p < 0.001). In follow-up BD patients, changes in serum CXCL10 levels tended to be correlated with those of BDCAF. The percentage of CXCR3 expression in CD3-positive cells in PBMCs was inversely correlated with serum CXCL10 levels in BD patients (p = 0.022). By immunohistochemistry, the number of CXCR3-positive mononuclear cells was higher in skin and intestinal lesions of BD patients than in those of HCs. These results suggest that the CXCL10/CXCR3 axis may contribute to the pathogenesis of BD.
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影响因子：
12.8
作者：
Takeuchi M;Kastner DL;Remmers EF
通讯作者：
Remmers EF
DOI：
10.3904/kjim.2016.31.1.170
发表时间：
2016-01
期刊：
The Korean journal of internal medicine
影响因子：
--
作者：
Choi HJ;Seo MR;Ryu HJ;Baek HJ
通讯作者：
Baek HJ
影响因子：
32.4
作者：
Zlotnik A;Yoshie O
通讯作者：
Yoshie O
影响因子：
24.1
作者：
Hamzaoui, Kamel;Borhani-Haghighi, Afshin;Hamzaoui, Agnes
通讯作者：
Hamzaoui, Agnes
影响因子：
4.9
作者：
Han, Jae Ho;Suh, Chang-Hee;Kim, Hyoun-Ah
通讯作者：
Kim, Hyoun-Ah