Pregnancy outcomes in healthy nulliparas who developed hypertension
Pregnancy outcomes in healthy nulliparas who developed hypertension
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DOI：
10.1016/s0029-7844(99)00462-7
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发表时间：
2000-01-01
影响因子：
7.2
通讯作者：
Morris, CD
中科院分区：
文献类型：
--
作者：
Hauth, JC;Ewell, MG;Morris, CD
目的：探讨妊高征或子痫前期妊高征孕妇的母婴结局。方法：我们进行了一项随机、双盲、安慰剂对照的试验，4589名健康的孕妇在妊娠13-21周补充钙。这一定义明确、特征明确的数据集提供了一个机会，可以更精确地详细描述在一系列健康无孕妇女中患高血压的孕妇、胎儿和新生儿的不良结局。结果：在4302名妊娠20周及以上的女性中，1073名（24.9%）出现轻度或重度妊娠相关高血压或先兆子痫。1073例高血压患者中有116例（10.8%），3229例无高血压患者中有336例（10.4%）在妊娠37周前分娩。两组胎儿和新生儿死亡率相似；然而，高血压妇女的产妇和新生儿发病率明显更高。显著增加的产妇发病率包括剖宫产、胎盘早剥和急性肾功能不全的增加；围产期发病率显著增加，包括呼吸窘迫综合征、呼吸支持和胎儿生长受限。严重妊娠高血压或子痫前期妇女的不良后果最高。结论：高血压，特别是严重高血压，与重要的孕产妇和围产期发病率的显著增加有关，但与围产期死亡率无关。[j] .妇产科杂志2000；95:24-8。(C) 2000年由美国妇产科医师学会出版。
Objective: To determine maternal and perinatal outcomes in nulliparas with pregnancy-associated hypertension or preeclampsia.Methods: We conducted land reported elsewhere) a randomized, double-masked, placebo-controlled trial calcium supplementation of 4589 healthy nulliparas assigned at 13-21 weeks' gestation. This well-defined and characterized data set provided an opportunity to detail more precisely adverse maternal, fetal, and newborn outcomes in women who developed hypertension among a prospective series of healthy nulliparas.Results: Of 4302 women observed to or beyond 20 weeks' gestation, 1073 (24.9%) developed mild or severe pregnancy-associated hypertension or preeclampsia. One hundred sixteen women of the 1073 with hypertension (10.8%) and 336 of the 3229 without hypertension (10.4%) were delivered before 37 weeks' gestation. Fetal and neonatal mortality were similar in those groups; however, selected maternal and newborn morbidities were significantly greater in women with hypertension. Significantly increased maternal morbidities included increased cesarean deliveries, abruptio placentae, and acute renal dysfunction; and significantly increased perinatal morbidities included respiratory distress syndrome, ventilatory support, and fetal growth restriction. Adverse outcomes were highest in women with severe pregnancy-associated hypertension or preeclampsia.Conclusion: Hypertension, especially severe hypertension, was associated with an appreciable increase in important maternal and perinatal morbidity but not perinatal mortality. (Obstet Gynecol 2000;95:24-8. (C) 2000 by The American College of Obstetricians and Gynecologists.).