Memory Formation in Tritonia via Recruitment of Variably Committed Neurons.
Memory Formation in Tritonia via Recruitment of Variably Committed Neurons.
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DOI：
10.1016/j.cub.2015.09.033
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发表时间：
2015-11-16
期刊：
影响因子：
--
通讯作者：
Frost WN
中科院分区：
文献类型：
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作者：
Hill ES;Vasireddi SK;Wang J;Bruno AM;Frost WN
先前的研究发现，功能性网络可以在建立短期记忆时快速添加神经元，但人们对这一过程的基本原理知之甚少。使用电压敏感染料成像，我们发现Tritonia的游泳运动程序的短期敏化涉及参与神经元数量的快速扩张。通过跟踪神经元的试验发现，这涉及到最近发现的可变参与神经元转换为可靠状态。此外，我们确定了一个候选人的β-胡萝卜素能细胞机制介导这一过程。我们的研究结果揭示了记忆形成的新机制，包括将预先定位的可变定向神经元招募到记忆网络中。这代表了该领域从长期关注突触可塑性，转向某些神经元具有使其易于加入具有学习能力的网络的特征。
Prior studies have found that functional networks can rapidly add neurons as they build short-term memories, yet little is known about the principles underlying this process. Using voltage-sensitive dye imaging we found that short-term sensitization of Tritonia’s swim motor program involves rapid expansion of the number of participating neurons. Tracking neurons across trials revealed that this involves the conversion of recently discovered variably-participating neurons to reliable status. Further, we identify a candidate serotonergic cellular mechanism mediating this process. Our findings reveal a new mechanism for memory formation, involving recruitment of pre-positioned, variably-committed neurons into memory networks. This represents a shift from the field’s long-term focus on synaptic plasticity, toward a view that certain neurons have characteristics that predispose them to join networks with learning.