Signal transduction and cytoskeletal activation in the neutrophil.
Signal transduction and cytoskeletal activation in the neutrophil.
复制标题
中性粒细胞中的信号转导和细胞骨架激活。
DOI：
10.1152/physrev.1987.67.1.285
复制
发表时间：
1987
影响因子：
33.6
通讯作者：
Sklar,LA
中科院分区：
文献类型：
--
作者：
Omann,GM;Allen,RA;Bokoch,GM;Painter,RG;Traynor,AE;Sklar,LA
N-甲酰肽、补体第五组分 (Ga) 的裂解产物、白三烯 B4 (LTBJ、血小板活化因子 (PAF) 和晶体诱导趋化因子 (CCF) 等趋化剂可刺激中性粒细胞的定向运动反应，并诱导细胞骨架和收缩装置发生快速而广泛的变化。这些变化已在 N-甲酰肽刺激的形态和生化水平上得到记录。当趋化肽与中性粒细胞相互作用时，可以观察到的最快速的形态变化是伪足在 2-5 秒内延伸（如果粘附在基质上）或细胞表面的整体起泡或褶皱（悬浮）（42,57,244）。
Chemoattractants such as N-formyl peptides, cleavage product of the fifth component of complement (Ga), leukotriene B4 (LTBJ, platelet-activating factor (PAF), and crystal-induced chemotactic factor (CCF) stimulate a directed motile response in neutrophils and induce rapid and extensive changes in the cytoskeleton and contractile apparatus. These changes have been documented at both the morphological and biochemical levels for N-formyl peptide stimulation. One of the most rapid morphological changes that can be observed when chemotactic peptides interact with neutrophils is the extension within 2-5 s of pseudopods (if adherent to a substratum) or a global blebbing or ruffling of the cell surface (in suspension)(42, 57, 244). Microscopic studies have shown that the pseudopods of migrating neu-