Sensing cell stress and transformation through Vγ9Vδ2 T cell-mediated recognition of the isoprenoid pathway metabolites
Sensing cell stress and transformation through Vγ9Vδ2 T cell-mediated recognition of the isoprenoid pathway metabolites
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DOI：
10.1016/j.micinf.2005.03.004
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发表时间：
2005-03-01
影响因子：
5.8
通讯作者：
Fournié, JJ
中科院分区：
文献类型：
--
作者：
Bonneville, M;Fournié, JJ
V γ V δ 2细胞是成人主要的外周血γ δ T细胞亚群，可识别非肽磷酸化代谢物，即磷酸抗原（phosphoAg），这些代谢物由广泛的原核和真核生物产生。我们将回顾导致磷酸银产生的生物合成途径以及我们目前对这些化合物激活V γ 9V δ 2细胞的模式的理解。我们还将讨论这种免疫识别过程的生理相关性，并展示它如何使感染和/或转化细胞的V γ 9V δ 2淋巴细胞能够识别。(c) 2005 Elsevier SAS。版权所有。
V gamma V delta 2 cells, a major peripheral blood gamma delta T cell subset in adults, recognize non-peptidic phosphorylated metabolites referred to as phosphoantigens (phosphoAg), which are produced by a broad array of prokaryotic and eukaryotic organisms. We will review here the biosynthetic pathways leading to production of phosphoAg and our current understanding of the mode of activation of V gamma 9V delta 2 cells by these compounds. We will also discuss the physiological relevance of this immune recognition process and show how it can enable discrimination by V gamma 9V delta 2 lymphocytes of infected and/or transformed cells. (c) 2005 Elsevier SAS. All rights reserved.