Determinants of age at menarche as early life predictors of breast cancer risk
Determinants of age at menarche as early life predictors of breast cancer risk
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DOI：
10.1002/(sici)1097-0215(19961009)68:2
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发表时间：
1996-10-09
影响因子：
6.4
通讯作者：
Trichopoulos, D
中科院分区：
文献类型：
--
作者：
Petridou, E;Syrigou, E;Trichopoulos, D
月经初潮年龄是少数已确定的乳腺癌危险因素之一；识别其外源性决定因素可能有助于揭示乳腺癌的起源。我们在希腊进行了一项流行病学研究，以确定：1)能量摄入量(一种体力活动的指标)是否与月经初潮年龄较晚有关；2)能量调整脂肪摄入量与月经初潮年龄较早相关；以及3)其他常量营养素和人体测量变量是月经初潮年龄的预测因素。通过对大雅典地区8所学校的345名9-16岁女学生的亲自访谈，研究了人体测量学、社会经济、熟悉度、营养和生活方式对月经初潮年龄的预测作用。月经初潮是比例风险模型中的结果变量，通过一系列预测变量评估相互调整的发病率比。在一项补充分析中，月经初潮年龄是月经女孩的因变量。主分析和补充分析得到了一致的结果。身高和体重指数的增加会加速月经初潮的发生。母亲和女儿的月经初潮年龄是相关的，但没有证据表明这与父亲的教育有关。适度体力活动的各种指标以及总能量摄入量的增加与月经初潮年龄的延迟有关。能量调整的常量营养素与月经初潮年龄无关。研究表明，通过增加体力活动改变早期生活中的能量平衡，可以推迟月经初潮的年龄，并降低晚年患乳腺癌的风险。(C)1996年Wiley-Liss，Inc.
Age at menarche is one of the few established risk factors for breast cancer; identification of its exogenous determinants could throw light on the origins of breast cancer. We have undertaken an epidemiologic study in Greece to ascertain whether: 1) energy intake, an indicator of physical activity, is associated with later age at menarche; 2) energy-adjusted fat intake is related to earlier age at menarche; and 3) other macronutrients and anthropometric variables are predictors of age at menarche. Anthropometric, socio-economic, familiar, nutritional and lifestyle predictors of age at menarche were studied by interviewing in person 345 female students 9 to 16 years old attending 8 schools of Greater Athens. Menarche was the outcome variable in a proportional hazards model assessing the mutually adjusted incidence rate ratio by a series of predictor variables. In a complementary analysis, age at menarche was the dependent variable among menstruating girls. Consistent results were derived from the main and the complementary analysis. Increased height and body mass index accelerate the occurrence of menarche. Maternal and daughter's ages at menarche are correlated, but there is no evidence of an association with paternal education. Various measures of moderate physical activity as well as increased total energy intake were associated with a delay in age at menarche. Energy-adjusted macronutrients were not associated with age at menarche. It appears that an alteration of energy balance in early life through increased physical activity could delay age at menarche and reduce the risk for breast cancer in later life. (C) 1996 Wiley-Liss, Inc.