Inhibition of hypoxia-induced cardiac hypertrophy by verapamil in rats
Inhibition of hypoxia-induced cardiac hypertrophy by verapamil in rats
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维拉帕米对大鼠缺氧性心肌肥厚的抑制作用
DOI：
10.1007/bf01910453
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发表时间：
1980
影响因子：
9.5
通讯作者：
M. Condorelli
中科院分区：
文献类型：
--
作者：
A. Genovese;M. Chiariello;A. Cacciapuoti;W. Alfieri;S. Latte;M. Condorelli
采用雄性Sprague-Dawley大鼠（200-220 g）研究钙拮抗剂对缺氧诱导的心肌肥厚的影响。通过将动物暴露于低压舱中的降低的大气压来获得低氧条件。将大鼠分组，暴露于急性或慢性间歇性缺氧（分别为每天0.42大气压空气24小时或每天0.42大气压空气12小时，持续10天）。以200 mg/kg/bw/大鼠的总剂量皮下给予维拉帕米（VRP）。在缺氧大鼠中，药物显著降低了根据其与总体重的关系计算的干心脏重量值。这种现象可能是由于：（1）收缩系统的激活减少，从而导致ATP分解减少，这是由于阻断Ca++流入心肌细胞;（2）维拉帕米对缺氧诱导的肺动脉高压的影响和/或（3）药物对心肌细胞的直接影响。
Male Sprague-Dawley rats (200-220 g) were employed to study the effect of a calcium antagonistic drug on hypoxia-induced myocardial hypertrophy. The hypoxic condition was obtained by exposure of animals to reduced barometric pressure in a hypobaric chamber. The rats, divided in groups, were exposed to acute or chronic intermittent hypoxia (0.42 atmospheres of air for 24 hrs or 0.42 atm for 12 hrs per day for 10 days, respectively). Verapamil (VRP) was given subcutaneously in a total dose of 200 mg/kg/bw/rat. In hypoxic rats, the drug significantly reduced the values of dry heart weight calculated on the basis of its relationship to total body weight. This phenomenon is probably due to:(1) reduced activation of the contractile system and a thereby resulting decrease in ATP breakdown as a result of blocking of Ca++ inflow into myocardial cells;(2) the effect of Verapamil on hypoxia-induced pulmonary hypertension and/or (3) a direct effect of the drug on the myocardial cell.