Heterosynaptic Plasticity Underlies Aversive Olfactory Learning in Drosophila.
Heterosynaptic Plasticity Underlies Aversive Olfactory Learning in Drosophila.
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DOI：
10.1016/j.neuron.2015.11.003
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发表时间：
2015-12-02
期刊：
影响因子：
16.2
通讯作者：
Turner GC
中科院分区：
文献类型：
--
作者：
Hige T;Aso Y;Modi MN;Rubin GM;Turner GC
虽然在许多动物中，联想学习已经局限于特定的大脑区域，但在体内识别潜在的突触过程一直很困难。在这里，我们提供了第一个演示的长期突触可塑性在果蝇蘑菇体的输出站点。将气味与特定多巴胺神经元的激活配对会诱导学习和气味特异性突触抑制。可塑性诱导严格依赖于两个刺激的时间顺序，复制联想学习的逻辑要求。此外，我们发现，多巴胺的行动是局限于不同的解剖隔间的蘑菇体叶。最后，我们发现，不同气味的稀疏表示之间的重叠定义了两个刺激特异性的可塑性和概括性的联想记忆的气味。因此，我们在这里发现的可塑性不仅体现了联想学习的重要特征，而且还提供了如何读出稀疏感觉代码的一般见解。
Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activation of specific dopamine neurons induces both learning and odor-specific synaptic depression. The plasticity induction strictly depends on the temporal order of the two stimuli, replicating the logical requirement for associative learning. Furthermore, we reveal that dopamine action is confined to and distinct across different anatomical compartments of the mushroom body lobes. Finally, we find that overlap between sparse representations of different odors defines both stimulus-specificity of the plasticity and generalizability of associative memories across odors. Thus, the plasticity we find here not only manifests important features of associative learning but also provides general insights into how a sparse sensory code is read out.