Development and validation of a scale of self-alienation-related attributes for the early diagnosis of schizophrenia
Development and validation of a scale of self-alienation-related attributes for the early diagnosis of schizophrenia
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用于精神分裂症早期诊断的自我异化相关属性量表的开发和验证
DOI：
10.1016/j.jpsychires.2022.01.020
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发表时间：
2022
影响因子：
4.8
通讯作者：
Suzuki Michio
中科院分区：
文献类型：
--
作者：
Nishiyama Shimako;Kurachi Masayoshi;Higuchi Yuko;Takahashi Tsutomu;Sasabayashi Daiki;Mizukami Yuko;Suzuki Michio
背景精神分裂症的发病通常有前驱期。然而，很难从前驱症状预测未来向精神分裂症的转变。根据施耐德一级症状（FRS），特别是代表“自我障碍”的FRS的诊断意义，（Ichstörungen）"，我们开发了一个自我异化相关属性量表（Self-A），以评估与自我障碍相关的心理特征，用于精神分裂症的早期诊断。和154名健康对照（HC）受试者参与了这项研究。自我-A量表由明尼苏达多相人格问卷（MMPI）中的项目构建，基于精神分裂症患者与非精神分裂症患者之间的差异，FRS代表被称为“自我异化症状”的自我障碍。自我-A量表的信度和效度进行了测试，在不同的样本的精神分裂症患者，然后适用于不同的队列，包括首发精神分裂症（FES）患者，ARMS个人，HC subject. ResultsSelf-A包括27个项目具有良好的内部一致性信度。自我-A量表得分与自我疏离症状得分的高度相关性证明了该量表的有效性。ARMS和FES组的自我A评分高于HC组。自我A得分在ARMS个人谁后来发展为精神分裂症高于在ARMS科目谁没有，并与FES group.ConclusionsThis研究表明，新开发的自我A量表评估自我异化相关的属性，可以提高精神分裂症的早期诊断。
BackgroundThe onset of schizophrenia is often preceded by a prodromal phase. However, it is difficult to predict the future transition to schizophrenia from the prodromal symptoms. Based on the diagnostic significance of Schneider's first rank symptoms (FRS), especially those representing “ego disorders (Ichstörungen)”, we developed a scale of self-alienation-related attributes (Self-A) to assess the psychological characteristics associated with ego disorders for the early diagnosis of schizophrenia.MethodsIn total, 153 schizophrenia (Sz) patients, 83 at-risk mental state (ARMS) subjects, and 154 healthy control (HC) subjects participated in this study. The Self-A scale was constructed by items from the Minnesota Multiphasic Personality Inventory (MMPI) based on the differences between schizophrenia patients with and without FRS representing ego-disorders designated as “self-alienation symptoms”. The Self-A scale was tested for its reliability and validity in a different sample of schizophrenia patients, and was then applied to different cohorts including first-episode schizophrenia (FES) patients, ARMS individuals, and HC subjects.ResultsThe Self-A consisting of 27 items exhibited good internal consistency reliability. The validity was well demonstrated by the high correlation of the Self-A scores with the self-alienation symptom scores. The ARMS and FES groups had higher Self-A scores than the HC group. The Self-A score in the ARMS individuals who later developed schizophrenia was higher than that in the ARMS subjects who did not, and was comparable with that in the FES group.ConclusionsThis study suggests that the newly developed Self-A scale assessing the self-alienation-related attributes can improve the early diagnosis of schizophrenia.