Monoterpenes and sesquiterpenes from the marine sediment-derived fungus Eutypella scoparia FS46
Monoterpenes and sesquiterpenes from the marine sediment-derived fungus Eutypella scoparia FS46
复制标题
来自海洋沉积物来源的真菌 Eutypella scoparia FS46 的单萜和倍半萜
DOI：
10.1080/10286020.2016.1189906
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发表时间：
2017-01-01
影响因子：
1.7
通讯作者：
Zhang, Wei-Min
中科院分区：
文献类型：
--
作者：
Liu, Hong-Xin;Zhang, Ling;Zhang, Wei-Min
摘要 从海洋沉积物真菌Eutypella scoparia 中分离出Eutypellol A (1)（第一个倍半萜类化合物）、Eutypellol B (2)（一种罕见的7-甲基氧化2-蒈烯衍生物）和一种新的天然产物2-(2-羟基-4-甲基环己-3-烯基)丙酸(3)，以及八种已知的萜类化合物。 FS46从南中国海采集。它们的结构是在广泛的光谱分析的基础上建立的。评估了化合物 1-3 对金黄色葡萄球菌的抗菌活性以及对 MCF-7、NCI-H460 和 SF-268 肿瘤细胞系的细胞毒活性。
Abstract Eutypellol A (1), the first norsesquiterpenoid of sequicarene family, as well as eutypellol B (2), a rare 7-methyl oxidized 2-carene derivative, and one new natural product 2-(2-hydroxy-4-methylcyclohex-3-enyl)propanoic acid (3), along with eight known terpenoids, were isolated from the marine sediment-derived fungus Eutypella scoparia FS46 collected from the South China Sea. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1–3 were evaluated for their antibacterial activities against Staphylococcus aureus and cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines.