Preparation and evaluation of pillararene bonded silica gel stationary phases for high performance liquid chromatography
Preparation and evaluation of pillararene bonded silica gel stationary phases for high performance liquid chromatography
复制标题
高效液相色谱柱芳烃键合硅胶固定相的制备及评价
DOI：
10.1016/j.chroma.2016.12.019
复制
发表时间：
2017
影响因子：
4.1
通讯作者：
Zhang Shusheng
中科院分区：
文献类型：
--
作者：
Zhao Wenjie;Chu Jianxiang;Xie Fuwei;Duan Qunpeng;He Lijun;Zhang Shusheng
以3-氨基丙基三乙氧基硅烷为偶联剂，制备了环芳烃键合高效液相色谱柱。用红外光谱、元素分析和热重分析对新材料的结构进行了表征。使用不同的溶质探针，包括田中测试溶质、多环芳烃、酚和芳香族位置异构体，以反相模式评价了新固定相的层析性能和保留机理。新的固定相可以为不同的溶质提供不同的相互作用，如疏水作用、氢键作用、π-π作用和包合作用。新主体分子中的芳环、氧原子、烷基连接体和空穴的协同作用通过多种保留机制提高了分离选择性。这种混合固定相可以提供更多的通用性，在复杂样品的分析中具有很大的潜力。
Pillararene bonded stationary phases for high performance liquid chromatography were prepared using 3-aminopropyltriethoxysilane as coupling reagent. The structure of the new materials was characterized by infrared spectroscopy, elemental analysis and thermogravimetric analysis. The chromatographic performance and retention mechanism of the new stationary phases were evaluated in reversed-phase mode compared with C18using different solute probes including Tanaka test solutes, polycyclic aromatic hydrocarbons, phenols and aromatic positional isomers. The new stationary phases could provide various interactions for different solutes, such as hydrophobic, hydrogen bonding,π-πand inclusion interactions. The synergistic effects resulting from aromatic rings, oxygen atoms, alkyl linkers and cavities in the new host molecules improved the separation selectivity by multiple retention mechanisms. Such hybrid stationary phases can provide more versatility and have great potential for the analysis of complex samples.