Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
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DOI：
10.22038/ajp.2019.42689.2426
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发表时间：
2020-05-01
影响因子：
2.2
通讯作者：
Ghobadi, Hassan
中科院分区：
文献类型：
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作者：
Aslani, Mohammad Reza;Matin, Somaieh;Ghobadi, Hassan
目的：慢性阻塞性肺疾病（COPD）的特点是全身炎症和肺部加速炎症。一些研究表明共轭亚油酸（CLA）具有抗炎作用。本研究的目的是评估补充 CLA 对 COPD 患者血清白细胞介素 (IL)-6 和 Sirtuin1 (SIRT1) 水平的影响。 材料和方法：82 名稳定期 COPD 患者参加了一项双盲临床试验。受试者被随机分配到两组：安慰剂组 (n=42) 和每日补充 3.2 g CLA (n=40)。在基线和干预后六周测量一秒用力呼气量 (FEV1%)、BODE 指数以及 IL-6 和 SIRT1 的血清水平。此外，根据全球慢性阻塞性肺疾病倡议（GOLD）标准对两组研究参数进行比较。结果：补充CLA后，血清IL-6和BODE指数水平显着下降（p
Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementation on serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients with COPD.Materials and Methods: 82 patients with stable COPD were enrolled in a double blind clinical trial. Subjects were randomly assigned to two groups: placebo (n=42) and 3.2 g CLA daily supplementation (n=40). Forced expiratory volume in one second (FEV1%), BODE index, and serum levels of IL-6, and SIRT1 were measured at the baseline and six weeks after the intervention. In addition, the study parameters in the two groups were compared based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.Results: After supplementation with CLA, serum levels of IL-6 and BODE index significantly decreased (p