Optimization of square microneedle arrays for increasing drug permeability in skin
Optimization of square microneedle arrays for increasing drug permeability in skin
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DOI：
10.1016/j.ces.2008.02.007
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发表时间：
2008-05-01
影响因子：
4.7
通讯作者：
Das, Diganta Bhusan
中科院分区：
文献类型：
--
作者：
AI-Qallaf, Baffak;Das, Diganta Bhusan
微针阵列是一种新的经皮给药技术，旨在在表皮中产生孔并穿透角质层，从而避免这种屏障的高阻力。已经证明，针头可以增加药物的皮肤渗透性，而没有疼痛或疼痛很小。然而，使用微针阵列时表皮的皮肤渗透性尚未得到充分研究。在一些情况下，基于某些标准（例如，微针的材料）必须与其它标准相关（例如，皮肤中的药物渗透性、皮肤厚度等）。因此，为了确定微针阵列的最佳设计，需要考虑不同因素（例如，微针的数量、贴片的表面积等）沿着使用微针的皮肤渗透性应准确测定。在这项工作中，高分子量药物的微针透皮给药的优化框架。该框架的输出使我们能够确定各种微针的最佳设计。然后使用来自该优化算法的数据来预测从微针系统注射到皮肤中的高分子量的皮肤渗透性。确定了优化的微针对血液药物浓度的影响。这项研究的结果是有用的，提出了一个基于不同的测量（例如，皮肤厚度的变化）用于药物的透皮递送。(c)2008爱思唯尔有限公司保留所有权利。
Microneedles array is a new transdermal drug delivery technique designed to create holes in the epidermis and penetrate the stratum corneum, thus avoiding the high resistance of this barrier. Microneedles have been shown to increase the skin permeability of drugs with no or little pain. However, the skin permeability of epidermis while using microneedle arrays has yet to be fully studied. In some cases, microneedle and microneedle array designs which were developed based on certain criteria (e.g., material of the microneedles) have to be related to other criteria (e.g., drug permeability in skin, skin thickness, etc.). Therefore, in order to determine the optimum design of the microneedle arrays, the effect of different factors (e.g., number of the microneedle, surface area of the patch, etc.) along with skin permeability by using microneedles should be determined accurately. In this work, an optimization framework for transdermal delivery of high molecular weight drug from microneedle is presented. The outputs of this framework have allowed us to identify the optimum design of various microneedles. Data from this optimization algorithm is then used to predict skin permeability of high molecular weight injected into the skin from a microneedle system. The effect of the optimized microneedles on blood drug concentration has been determined. The outcome of this study is useful to propose an optimum design based on different measurement (e.g., variation of skin thickness) for transdermal delivery of drugs. (c) 2008 Elsevier Ltd. All rights reserved.