Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.
Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver.
复制标题
原位大鼠肝脏中三重量子过滤 23Na NMR 光谱的评估。
DOI：
10.1002/mrm.1910380519
复制
发表时间：
1997
影响因子：
3.3
通讯作者：
Bansal,N
中科院分区：
文献类型：
--
作者：
Seshan,V;Sherry,AD;Bansal,N
Triple quantum (TQ)‐filtered23Na NMR spectroscopy and the shift reagent, TmDOTP5‐, have been used to evaluate the contributions of intra‐ (Nai+) and extracellular (Nae+) sodium to the TQ‐filtered signal in the rat liver,in situ.Nae+contributed significantly to the total TQ‐filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ‐filtered Nai+signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Nai+increased by 90%. The constancy of the TQ‐filtered Nae+signal indicates that changes in total TQ‐filtered23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ‐filtered Nai+signal intensity. The large percent increase in the TQ‐filtered Nai+signal as compared to the SQ signal suggests that the fraction of Nai+interacting with macromolecules increases after death.
