Pd(II)-Catalyzed Tandem Heterocyclization of 1-(1-Alkynyl)cyclopropyl Oxime Derivatives for the Synthesis of Functionalized Pyrroles.
Pd(II)-Catalyzed Tandem Heterocyclization of 1-(1-Alkynyl)cyclopropyl Oxime Derivatives for the Synthesis of Functionalized Pyrroles.
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DOI：
10.1021/acs.orglett.6b02068
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发表时间：
2016-07
期刊：
影响因子：
5.2
通讯作者：
D. Pan;Yin Wei;M. Shi
中科院分区：
文献类型：
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作者：
D. Pan;Yin Wei;M. Shi
以1-（1-炔基）环丙基肟衍生物为原料，在Pd（TFA）2催化下，在温和条件下进行串联杂环化反应，合成了高功能化的吡咯类化合物.该反应首先通过分子内亲核攻击，然后通过开环过程，然后通过分子间亲核攻击以及质子化进行，以中等至优异的产率得到所需的产物。
An efficient approach for the synthesis of highly functionalized pyrroles has been developed by a Pd(TFA)2-catalyzed tandem heterocyclization of 1-(1-alkynyl)cyclopropyl oxime derivatives under mild conditions. The reaction first proceeded via an intramolecular nucleophilic attack followed by a ring-opening process and then intermolecular nucleophilic attack as well as protonation to afford the desired products in moderate to excellent yields.