INHIBITION OF LEISHMANIAS BUT NOT HOST MACROPHAGES BY THE ANTITUBULIN HERBICIDE TRIFLURALIN
INHIBITION OF LEISHMANIAS BUT NOT HOST MACROPHAGES BY THE ANTITUBULIN HERBICIDE TRIFLURALIN
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DOI：
10.1126/science.2392684
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发表时间：
1990-08-24
期刊：
影响因子：
56.9
通讯作者：
FONG, D
中科院分区：
文献类型：
--
作者：
CHAN, MMY;FONG, D
二硝基苯胺除草剂氟乐灵（α，α，α-三氟-2，6-二硝基-N，N-二丙基-对甲苯胺），在微摩尔浓度下，选择性地抑制寄生原生动物Leishmania mexicana amazonensis的增殖和分化。在体外，放射性氟乐灵表现出特异性结合利什曼原虫微管蛋白，但不哺乳动物微管蛋白。由于除草剂如氟乐灵是经济的，并且被认为对人类和家养动物是安全的，它们可以作为潜在的抗寄生虫剂的有用来源。
The dinitroaniline herbicide trifluralin (α, α, α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine), at micromolar concentrations, selectively inhibited both proliferation and differentiation of the parasitic protozoanLeishmania mexicana amazonensis. In vitro, radioactive trifluralin showed specific binding to leishmania tubulin but not to mammalian tubulin. Because herbicides such as trifluralin are economical and are considered safe for man and domesticated animals, they may serve as useful sources of potential antiparasitic agents.