Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease
Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease
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DOI：
10.1007/s004390050480
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发表时间：
1997-07-01
期刊：
影响因子：
5.3
通讯作者：
Shibahara, S
中科院分区：
文献类型：
--
作者：
Kimpara, T;Takeda, A;Shibahara, S
氧化应激被认为与阿尔茨海默病(AD)和帕金森病(PD)等神经退行性疾病的发病机制有关。血红素加氧酶-1(HO-1)是血红素分解代谢的关键酶，也是一种抗氧化酶。在这里，我们证明了人类HO-1基因启动子区域的(GT)(N)重复是高度多态的，尽管没有特定的等位基因与AD或PD相关。这个新发现的遗传标记应该可以让我们研究HO-1在某些人类疾病中的可能参与。
Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)(n) repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.