On the Biomechanics of Cardiac S-Looping in the Chick: Insights From Modeling and Perturbation Studies.
On the Biomechanics of Cardiac S-Looping in the Chick: Insights From Modeling and Perturbation Studies.
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关于小鸡心脏 S 环的生物力学：来自建模和扰动研究的见解。
DOI：
10.1115/1.4043077
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Gangi,Lianna
中科院分区：
文献类型：
--
作者：
Ramasubramanian,Ashok;Capaldi,Xavier;Bradner,SarahA;Gangi,Lianna
心脏环是一个重要的胚胎发育阶段，在这个阶段，原始心管(HT)扭曲成更接近成熟心脏的形状。不适当的环路会导致先天性缺陷。本文以鸡胚胎为实验模型，研究了心脏S环，即位于心房上方的原始脑室现在呈现其位于其下方的确切位置。这个过程导致心脏环路不再是平面的，流入和流出的区域现在位于相邻的平面上。我们研究了S回旋的生物力学，并通过建模来理解非线性和时变的形态发生变化。我们建立了物理模型和有限元模型，并使用摄动研究对模型进行了验证。实验和模型的结果显示了力致动器，如胚胎背壁的弯曲(颈曲)、围绕体轴的旋转(胚胎扭转)和HT生长是如何相互作用来产生心环的。利用基于模型的实验数据，我们提出了一种改进的早期心脏S环假说。
Cardiac looping is an important embryonic developmental stage where the primitive heart tube (HT) twists into a configuration that more closely resembles the mature heart. Improper looping leads to congenital defects. Using the chick embryo as the experimental model, we study cardiac s-looping wherein the primitive ventricle, which lay superior to the atrium, now assumes its definitive position inferior to it. This process results in a heart loop that is no longer planar with the inflow and outflow tracts now lying in adjacent planes. We investigate the biomechanics of s-looping and use modeling to understand the nonlinear and time-variant morphogenetic shape changes. We developed physical and finite element models and validated the models using perturbation studies. The results from experiments and models show how force actuators such as bending of the embryonic dorsal wall (cervical flexure), rotation around the body axis (embryo torsion), and HT growth interact to produce the heart loop. Using model-based and experimental data, we present an improved hypothesis for early cardiac s-looping.