The Role of Pyruvate Kinase M2 in Cancer Metabolism
The Role of Pyruvate Kinase M2 in Cancer Metabolism
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DOI：
10.1111/bpa.12311
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发表时间：
2015-11-01
期刊：
影响因子：
6.4
通讯作者：
Vander Heiden, Matthew G.
中科院分区：
文献类型：
--
作者：
Liu, Vivian M.;Vander Heiden, Matthew G.
M2亚型的丙酮酸激酶在癌细胞中优先表达，而不是其他的丙酮酸激酶亚型。PKM2的独特之处在于它能够受营养物质和生长信号通路的变构调节，使细胞适应不同环境中的生理需求。在这里，我们讨论了丙酮酸激酶M2在胶质瘤和癌症代谢中的作用。
The M2 isoform of pyruvate kinase is expressed preferentially in cancer cells over other pyruvate kinase isoforms. PKM2 is unique in its ability to be regulated allosterically by nutrients and growth signaling pathways, allowing cells to adapt their metabolic program to match physiological needs in different environments. Here, we discuss the role of pyruvate kinase M2 in glioma and in cancer metabolism.