Release of corrosion products by F-75 cobalt base alloy in the rat. III: Effects of a carbon surface coating.
Release of corrosion products by F-75 cobalt base alloy in the rat. III: Effects of a carbon surface coating.
复制标题
F-75钴基合金在大鼠体内释放腐蚀产物。
DOI：
10.1002/jbm.820211005
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
C. C. Clark
中科院分区：
文献类型：
--
作者：
J. Black;P. Oppenheimer;D. M. Morris;A. Peduto;C. C. Clark
F-75铬钴钼合金上应用了热解碳涂层，以减少体内腐蚀产物的释放。在大鼠肌肉内植入后，观察到铬、钴和镍的血清和尿液浓度升高的复杂模式。碳涂层植入物比未涂层的对照组释放更多的铬和钴，血清和尿液中的金属浓度显着升高即可看出。接受碳涂层植入物的动物表现出很高的植入部位炎症复发率。 24 只带有涂层植入物的动物出现肿瘤浸润，但接受未涂层 F-75 微球或聚乙烯颗粒植入物的 16 只动物中没有肿瘤浸润。
A pyrolytic carbon coating was applied to F-75 chromium-cobalt-molybdenum alloy in an effort to reduce the release of corrosion products in vivo. After intramuscular implantation in the rat, a complex pattern of serum and urine concentration elevations of chromium, cobalt, and nickel was seen. The carbon-coated implants released more chromium and cobalt than uncoated controls, as seen by significantly elevated metal concentrations in serum and urine. Animals receiving carbon-coated implants showed a high rate of recurrent implant site inflammation. Neoplastic infiltration of 24 animals with coated implants, but not in any of the 16 animals which received either uncoated F-75 microsphere or poly(ethylene) particulate implants.