Visceral fat obesity contributes to the tortuosity of the thoracic aorta on chest radiograph in poststroke Japanese patients
Visceral fat obesity contributes to the tortuosity of the thoracic aorta on chest radiograph in poststroke Japanese patients
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DOI：
10.1177/000331970605700112
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发表时间：
2006-01-01
期刊：
影响因子：
2.8
通讯作者：
Sakamaki, T
中科院分区：
文献类型：
--
作者：
Mochida, M;Sakamoto, H;Sakamaki, T
胸片上的胸主动脉扭曲是动脉粥样硬化疾病的特征。年龄和高血压与扭曲有关，但对其他动脉粥样硬化危险因素对这种异常的影响知之甚少。本研究的目的是探讨哪些动脉粥样硬化危险因素是胸主动脉扭曲的决定因素。选取日本脑卒中后患者45例（男31例，女14例，年龄41 ~ 78岁，平均60.5±- 8.6岁），采用距离因子，即曲流血管长度与其终点之间的直线距离之比来衡量动脉弯曲程度。查阅了医院的临床和生化记录。胸主动脉扭曲度与体重指数（BMI） （r = 0.397, p < 0.01）、腰围（r = 0.360, p < 0.05）、心胸比（CTR） （r = 0.526, p < 0.001）呈显著正相关，与踝肱压指数（ABPI）呈显著负相关（r = -0.360, p < 0.05）。逐步回归分析显示，腰围和CTR与扭曲度增加独立相关，而ABPI与扭曲度增加负相关。这些结果表明，内脏脂肪肥胖是胸主动脉扭曲的一个新因素，这可能是由于腹内脂肪过多导致横膈膜升高导致主动脉栓系点之间的距离缩短，也可能是由于肥胖相关代谢紊乱导致动脉硬化导致主动脉延长。
Tortuosity of the thoracic aorta on chest radiographs is characteristic of atherosclerotic disease. Aging and hypertension are associated with the tortuosity, but little is known about the influence of other atherosclerotic risk factors on this abnormality. The purpose of this study was to examine which atherosclerotic risk factors are determinants for tortuosity of the thoracic aorta. Forty-five poststroke Japanese patients (31 men and 14 women, age range 41-78 years and mean 60.5 +/- 8.6) were studied, The distance factor, ie, the ratio of meandering vessel length to the straight-line distance between its end points, was used to measure arterial tortuosity. The hospital records were reviewed for clinical and biochemical variables. Tortuosity of the thoracic aorta had a significant positive relationship with body mass index (BMI) (r = 0.397, p < 0.01), waist circumference (r = 0.360, p < 0.05), and the cardiothoracic ratio (CTR) (r = 0.526, p < 0.001), and a significant negative relationship with ankle-brachial pressure index (ABPI) (r = -0.360, p < 0.05). Stepwise regression analysis showed that waist circumference and CTR were independently correlated with increased tortuosity, whereas ABPI was negatively correlated with it. These results suggest that visceral fat obesity is a novel contributor to tortuosity of the thoracic aorta, which may be as a shortening of the distance between aortic tethering points due to elevation of the diaphragm by excessive intraabdominal fat and as a consequence of aortic elongation due to arteriosclerosis caused by obesity-related metabolic disorders.