Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome
Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome
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DOI：
10.1016/j.neurobiolaging.2011.08.007
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发表时间：
2012-09-01
影响因子：
4.2
通讯作者：
van Duijn, Cornelia M.
中科院分区：
文献类型：
--
作者：
Coppus, Antonia M. W.;Schuur, Maaike;van Duijn, Cornelia M.
淀粉样β蛋白(Aβ)的胞外沉积是阿尔茨海默病(AD)发病机制中的关键步骤。在唐氏综合征(DS)中，阿尔茨海默病被认为是由位于21号染色体的淀粉样前体蛋白(APP)基因的三倍体和过度表达引起的。在一项以人群为基础的研究中，对506名DS患者进行了血浆Aβ1-40和Aβ1-42浓度的测定，这些人每年都要进行痴呆症筛查。我们使用Cox比例风险模型来确定痴呆症的风险。痴呆组DS患者血浆Aβ1-40浓度显著高于非痴呆组(p=0.05)。那些Aβ1-40和Aβ1-42浓度最高的人患痴呆症的风险更高。在随访期间(平均4.7年)，Aβ1-42和Aβ1-40患痴呆症的风险分别增加到2.56(95%可信区间，1.39-4.71)和2.16(95%可信区间，1.14-4.10)。血浆中高浓度的Aβ1-40和Aβ1-42是DS患者痴呆风险的决定因素。(C)2012 Elsevier Inc.保留所有权利。
Extracellular deposition of amyloid beta peptide (A beta) has been implicated as a critical step in the pathogenesis of Alzheimer's disease (AD). In Down syndrome (DS), Alzheimer's disease is assumed to be caused by the triplication and overexpression of the gene for amyloid precursor protein (APP), located on chromosome 21. Plasma concentrations of A beta 1-40 and A beta 1-42 were determined in a population based study of 506 persons with DS, who were screened annually for dementia. We used Cox proportional hazards models to determine the risk of dementia. Demented persons with DS have a significantly higher plasma A beta 1-40 concentration than the nondemented (p = 0.05). Those with the highest concentrations of A beta 1-40 and A beta 1-42 have a higher risk to develop dementia. The risk to develop dementia during follow-up (mean 4.7 years) increased to 2.56 (95% confidence interval, 1.39-4.71) for A beta 1-42 and 2.16 (95% confidence interval, 1.14-4.10) for A beta 1-40. High plasma concentration of plasma A beta 1-40 and A beta 1-42 are determinants of the risk of dementia in persons with DS. (C) 2012 Elsevier Inc. All rights reserved.