Urban-rural environmental exposure during childhood and subsequent risk of inflammatory bowel disease: a meta-analysis
Urban-rural environmental exposure during childhood and subsequent risk of inflammatory bowel disease: a meta-analysis
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儿童时期城乡环境暴露及随后的炎症性肠病风险：一项荟萃分析
DOI：
10.1080/17474124.2018.1511425
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发表时间：
2019
影响因子：
3.9
通讯作者：
Xie Yong
中科院分区：
文献类型：
--
作者：
Song Conghua;Yang Jinpu;Ye Wen;Zhang Yuting;Tang Chunyan;Li Xiaomei;Zhou Xiaojiang;Xie Yong
背景资料：在城市和农村地区的生活条件之间的关系，在儿童和随后的炎症性肠病（IBD）仍然存在争议。目的：探讨在生命早期的环境暴露和随后的IBD的风险之间的关联。方法：在以下数据库进行文献检索：PubMed，EMBASE和会议论文引文索引。研究进行了分析，分别使用率比（RR）或比值比（OR）与95%的置信区间。其中，9项研究探讨了儿童时期城市暴露与溃疡性结肠炎（UC）之间的关系，12项和4项研究分别探讨了这种关系与克罗恩病（CD）和IBD。一项荟萃分析显示，UC、CD和IBD病例对照研究的合并OR估计值分别为1.16（0.83，1.61）、1.45（1.45，1.85）和1.34（1.11，1.62）。CD和IBD队列研究的汇总RR估计值为1.48（1.17，1.87）。分层分析和荟萃回归分析显示，在2010-2017年发表的病例对照研究和非欧洲国家中，CD与生活条件之间存在显著相关性（P<0. 05）。结论：儿童时期的生活条件与IBD的后续发展呈正相关。城市生活环境在CD患者中比UC患者更常见。
Background: The relationship between living conditions in urban and rural areas during childhood and subsequent inflammatory bowel disease (IBD) remains controversial.Aim: To explore the association between environmental exposures early in life and the subsequent risk of IBD.Methods: Literature searches were conducted in the following databases: PubMed, EMBASE, and Conference Proceedings Citation Index. Studies were analyzed separately using rate ratios (RRs) or odds ratios (ORs) with 95% confidence intervals.Results: The search strategy identified 15 studies. Of these, 9 studies explored the association between urban exposure during childhood and ulcerative colitis (UC), and 12 and 4 studies explored this relationship with Crohn’s disease (CD) and IBD, respectively. A meta-analysis showed that the pooled ORs estimated for the case–control studies of UC, CD, and IBD were 1.16 (0.83, 1.61), 1.45 (1.45, 1.85), and 1.34 (1.11, 1.62), respectively. The pooled RR estimated for the cohort studies of CD and IBD was 1.48 (1.17, 1.87). The stratified analysis and meta-regression showed significant relationships between CD and living conditions in case–control studies published during 2010–2017 and in non-European countries (P< 0.05).Conclusions: Living conditions during childhood are positively associated with the subsequent development of IBD. Urban living environment is more common among those with CD than UC.