Metabolomics comparison of Chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv
Metabolomics comparison of Chemical components and metabolic regulations in different parts of Eucommia ulmoides Oliv
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DOI：
10.1016/j.arabjc.2022.104304
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发表时间：
2022-09
影响因子：
6
通讯作者：
Xin Dong;Jie Liu;Shujing Guo;Fan Yang;R. Bu;Jingkun Lu;Peifeng Xue
中科院分区：
文献类型：
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作者：
Xin Dong;Jie Liu;Shujing Guo;Fan Yang;R. Bu;Jingkun Lu;Peifeng Xue
杜仲(EU)是一种具有多种药理活性的草本植物。随着对欧盟作为医疗来源的需求增加，其有限的可用性正成为一个紧迫的问题。杜仲皮是杜仲的主要药用部位，但其产量一直很低，难以满足市场需求。欧盟leopsis-Eucomiaefolium（EF）-容易从树木中获得，传统上被认为比欧盟树皮更有价值。本研究利用代谢组学方法比较了欧盟不同地区的化学成分和代谢规律，以探索欧盟替代医学来源的潜力。结果表明，EC和EF的组成略有不同，EC和EF的单个成分的含量存在一定差异。结合药效学/代谢组学分析，EC和EF均能改善去卵巢大鼠骨代谢指标和骨小梁微结构，主要通过干预氨基酸代谢实现。我们的数据表明，EF是一个潜在的替代医学选择时，欧盟资源稀缺，这项研究提供了一个机制框架的EF在骨质疏松症疾病的好处。
Eucommia ulmoidesOliv. (EU) is an herb with variety of pharmacological activities. As the demand for EU as a medical source increases, its limited availability is becoming an urgent problem. The bark of EU—Eucommiacortex (EC)—was the main medicinal part of EU, whose yield has been too low to meet market requirements. The EU leaves—Eucommiaefolium (EF)—obtained easily from the trees, traditionally considered less valuable than the EU bark. This study compared chemical components and metabolic regulations in different parts of EU using metabolomics to explore the potential for alternative medical sources of EU. The results demonstrated that the composition of EC differs slightly from the composition of EF, and there are some differences in the content of individual ingredients between EC and EF. Combined pharmacodynamic/metabolomics analysis showed that both EC and EF could improve the bone metabolism markers and trabecular microarchitecture of ovariectomized rats mainly by intervening in amino acid metabolism. Our data suggest that EF is a potential alternative medicinal option when EU resources are scarce, and this study provides a mechanistic framework for the benefits of EF in osteoporosis disease.