Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity
Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity
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DOI：
10.1021/ja062740z
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发表时间：
2006-07-19
影响因子：
15
通讯作者：
Wong, Chi-Huey
中科院分区：
文献类型：
--
作者：
Fujio, Masakazu;Wu, Douglass;Wong, Chi-Huey
在α-GalCer的脂肪酰链上引入芳香族基团，通过CD1d介导的NKT细胞的激活，调节γ/IL-4分泌的活性和选择性。化合物14−16比α-Galercer更有效，对干扰素-γ比IL-4有偏向。这些新的糖脂可能被用作佐剂或抗转移剂。
Introduction of an aromatic group into the fatty acyl chain of α-GalCer modulates the activity and selectivity of IFN-γ/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound14−16are more potent than α-Galcer and biased for IFN-γ than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.