Pericytes at the intersection between tissue regeneration and pathology.
Pericytes at the intersection between tissue regeneration and pathology.
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DOI：
10.1042/cs20140278
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Delbono O
中科院分区：
文献类型：
--
作者：
Birbrair A;Zhang T;Wang ZM;Messi ML;Mintz A;Delbono O
血管周围多能细胞，周细胞，有助于响应损伤的各种组织的生成和修复。它们在形态、分布、起源和标志物上是异质的，阐明它们的分子和细胞差异可能为组织再生受损或过度的疾病提供新的治疗方法。此外，这些发现为许多疾病的治疗方法提供了新的细胞靶点。本文综述了最近的研究支持的概念，周细胞亚型发挥独特的作用，在肌肉发生，神经发生，脂肪形成，纤维形成和血管生成。
Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support the concept that pericyte subtypes play a distinctive role in myogenesis, neurogenesis, adipogenesis, fibrogenesis and angiogenesis.