Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo
Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo
复制标题
DOI：
10.1016/s1074-7613(00)80043-6
复制
发表时间：
1999-04-01
期刊：
影响因子：
32.4
通讯作者：
Burtons, DR
中科院分区：
文献类型：
--
作者：
Poignard, P;Sabbe, R;Burtons, DR
如果在病毒攻击时存在适当浓度的中和抗体，则可以在体内抵抗HIV-1的攻击，但在控制已建立的感染中的任何作用尚不清楚。在这里，我们发现高浓度的中和性单克隆抗体，无论是单独使用还是混合使用，对hu-PBL-SCID小鼠中已建立的HIV-1感染的病毒载量几乎没有持续的影响。在某些情况下，即使存在高水平的中和抗体，中和敏感病毒的病毒复制仍在继续。在大多数情况下，中和逃逸在几天内发生，即使是三种识别不同表位的抗体的混合物。结果表明，体液免疫不太可能在控制人类HIV-1感染中发挥重要作用。
Neutralizing antibodies can protect against challenge with HIV-1 in vivo if present at appropriate concentrations at the time of viral challenge, but any role in the control of established infection is unclear. Here, we show that high serum concentrations of neutralizing monoclonal antibodies, either singly or as a cocktail, have little sustained effect on viral load in established HIV-1 infection in hu-PBL-SCID mice. In some instances, virus replication of neutralization-sensitive virus continues even in the presence of high levels of neutralizing antibody. In most instances, neutralization escape occurs in a few days, even from a cocktail of three antibodies that recognize distinct epitopes. The results imply that humoral immunity is unlikely to play a significant role in the control of established HIV-1 infection in humans.