Inhibitors against glycosidases as medicines.
Inhibitors against glycosidases as medicines.
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作为药物的糖苷酶抑制剂。
DOI：
10.2174/156802609787354333
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发表时间：
2009
影响因子：
3.4
通讯作者：
M. Node
中科院分区：
文献类型：
--
作者：
T. Kajimoto;M. Node
糖苷酶介导小肠中寡糖的消化以及细胞表面寡糖的加工，其在感染、转移和免疫应答期间的细胞与细胞识别中起重要作用。因此，控制糖苷酶活性的药剂可对许多碳水化合物相关疾病具有治疗效果。事实上，人们已经做了许多卓有成效的努力来设计和合成糖苷酶抑制剂作为临床实用的药物。本文综述了目前阶段的发展，这样的抑制剂治疗糖尿病，流感，病毒感染的艾滋病毒，肿瘤转移，和糖基鞘脂（GSL）储存疾病。
Glycosidases mediate the digestion of oligosaccharides in the small intestine as well as the processing of cell surface oligosaccharides, which play important roles in cell to cell recognition during infections, metastasis, and immune responses. Thus, agents that control the activities of glycosidases could have therapeutic effects against many carbohydrate-related diseases. In fact, many fruitful efforts have been made to design and synthesize glycosidase inhibitors as clinically practical medicines. This review summarizes the current stage of development of such inhibitors to treat diabetes, influenza, virus infection of HIV, tumor metastasis, and glycosyl sphingo lipid (GSL) storage diseases.