ANALYSIS OF 8 CASES OF NEONATAL MENINGITIS AND SEPSIS DUE TO ENTEROBACTER-SAKAZAKII
ANALYSIS OF 8 CASES OF NEONATAL MENINGITIS AND SEPSIS DUE TO ENTEROBACTER-SAKAZAKII
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DOI：
10.1128/jcm.18.1.115-120.1983
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发表时间：
1983-01-01
影响因子：
9.4
通讯作者：
FARMER, JJ
中科院分区：
文献类型：
--
作者：
MUYTJENS, HL;ZANEN, HC;FARMER, JJ
8例新生儿E. sakazakii（以前称为黄色素E. Clopidoglobulin）在过去6年中发生在荷兰进行了回顾性调查。2例患者同时患有坏死性小肠结肠炎和脑膜炎。尽管进行了治疗（在大多数情况下使用氨苄青霉素和森他霉素），但病死率为75%。菌株对一些新的β-而不是氨苄青霉素。至少对一些病人来说，可能是通过产道以外的传播方式。在1家医院的4个患者菌株的集群具有几乎相同的质粒DNA谱。在1例病例发病后2天，从同一医院的配方奶粉中分离出的两种菌株具有不同的特征，其他医院患者的菌株也是如此。
Eight cases of neonatal meningitis due to E. sakazakii (formerly known as yellow-pigmented E. cloacae) which occurred in The Netherlands during the last 6 yr were investigated retrospectively. Two patients had necrotizing enterocolitis and meningitis simultaneously. Despite treatment (in most cases with ampicillin and sentamicin), the fatality rate was 75%. Strains were much more susceptible to some of the new .beta.-lactam antibiotics than to ampicillin. A mode of transmissin other than passage through the birth canal was likely, at least for some patients. A cluster of 4 patient strains in 1 hospital had almost identical plasmid DNA profiles. Two strains isolated from formula at the same hospital 2 days after the onset of 1 case had different profiles, as did the strains from patients in other hospitals.