Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation
Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation
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DOI：
10.1016/j.ajog.2012.08.015
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发表时间：
2012-11-01
影响因子：
9.8
通讯作者：
Jackson, Aimee
中科院分区：
文献类型：
--
作者：
Caritis, Steve N.;Sharma, Shringi;Jackson, Aimee
目的：本研究的目的是估计单胎妊娠17-羟孕酮己酸（17-OHPC）的药动学参数并评估其胎盘转运。研究设计：61名每周接受17-OHPC注射的妇女在妊娠20 + 0至24 + 6周（研究1）和31 + 0至34 + 6周（研究2）进行了2项药代动力学研究；注射之间每天采集血液样本。在18名妇女中，在最后一次注射后的28天内获得了血液样本（扩展研究）。分娩时采集母体和/或脐带血。结果：17-OHPC的半衰期（中位+/- SD）为16.2 +/- 6天。研究2中17-OHPC的浓度高于研究1。体重指数影响母体17-OHPC浓度。脐带：产妇17-OHPC浓度比平均为0.2；最后一次注射后44天脐带血浆中可检出17-OHPC。结论：17-OHPC的表观半衰期长，药代动力学参数在受试者之间差异较大，且受母体体重指数的影响。药物穿过胎盘屏障。
OBJECTIVE: The purpose of this study was to estimate pharmacokinetic parameters and to evaluate placental transport of 17-hydroxyprogesterone caproate (17-OHPC) in singleton gestation.STUDY DESIGN: Sixty-one women who received weekly injections of 17-OHPC underwent 2 pharmacokinetic studies at 20 + 0 to 24 + 6 weeks' gestation (study 1) and 31 + 0 to 34 + 6 weeks' gestation (study 2); daily blood samples were obtained between injections. In 18 women, blood samples were obtained over a 28-day period beyond the last injection (extended study). Maternal and/or cord blood were obtained at delivery.RESULTS: The half-life (median +/- SD) of 17-OHPC was 16.2 +/- 6 days. Concentrations of 17-OHPC were higher during study 2 than during study 1. Body mass index affected maternal 17-OHPC concentrations. Cord: maternal 17-OHPC concentration ratios averaged 0.2; 17-OHPC was detectible in cord plasma 44 days after the last maternal injection.CONCLUSION: The apparent half-life of 17-OHPC is long, and pharmacokinetic parameters vary widely between subjects and are affected by maternal body mass index. The drug crosses the placental barrier.