Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?
Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?
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DOI：
10.1146/annurev-neuro-110920-011929
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发表时间：
2022-07-08
影响因子：
13.9
通讯作者：
中科院分区：
文献类型：
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作者：
大脑被盖区（VTA）的多巴胺（DA）神经元通常被认为是一致编码奖励预测错误。相反，多巴胺释放在脑桥核（NAc），这些神经元的突出的投射目标，已经牵连在强化学习，动机，厌恶和激励显着性。DA释放的异质功能与DA神经元活动的同质作用之间的这种对比引起了许多关于VTA DA活动如何转化为NAc DA释放的问题。使这个问题进一步复杂化的是，越来越多的证据表明，不同的腹侧被盖区DA投射到定义的NAc亚区介导不同的行为功能。在这里，我们评估证据的异质性中脑DA系统内，并认为，DA功能的框架必须纳入精确的地形组织腹侧被盖区DA神经元，以澄清其对健康和疾病的贡献。
Ventral tegmental area (VTA) dopamine (DA) neurons are often thought to uniformly encode reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the prominent projection target of these neurons, has been implicated in reinforcement learning, motivation, aversion, and incentive salience. This contrast between heterogeneous functions of DA release versus a homogeneous role for DA neuron activity raises numerous questions regarding how VTA DA activity translates into NAc DA release. Further complicating this issue is increasing evidence that distinct VTA DA projections into defined NAc subregions mediate diverse behavioral functions. Here, we evaluate evidence for heterogeneity within the mesoaccumbal DA system and argue that frameworks of DA function must incorporate the precise topographic organization of VTA DA neurons to clarify their contribution to health and disease.
DOI：
10.1016/j.pbb.2017.02.006
发表时间：
2018-11
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
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作者：
Cardozo Pinto DF;Lammel S
通讯作者：
Lammel S