Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian Declines
Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian Declines
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DOI：
10.1126/science.1176765
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发表时间：
2009-10-23
期刊：
影响因子：
56.9
通讯作者：
Speare, Rick
中科院分区：
文献类型：
--
作者：
Voyles, Jamie;Young, Sam;Speare, Rick
引起皮肤疾病壶菌病的病原体壶菌病（Batrachochytrium dendroatidis, Bd）是脊椎动物中为数不多的剧毒真菌之一，与世界范围内两栖动物数量下降有关。然而，Bd导致死亡的机制尚未确定。我们表明，Bd感染与导致绿树蛙（Litoria caerulea）死亡的病理生理变化有关。在患病个体中，电解质通过表皮的运输被抑制了50%，血浆钠和钾浓度分别降低了20%和50%，心脏骤停导致死亡。由于皮肤对维持两栖动物体内平衡至关重要，皮肤功能的破坏可能是Bd在许多系统发育遥远的两栖动物类群中产生发病率和死亡率的机制。
The pathogen Batrachochytrium dendrobatidis (Bd), which causes the skin disease chytridiomycosis, is one of the few highly virulent fungi in vertebrates and has been implicated in worldwide amphibian declines. However, the mechanism by which Bd causes death has not been determined. We show that Bd infection is associated with pathophysiological changes that lead to mortality in green tree frogs (Litoria caerulea). In diseased individuals, electrolyte transport across the epidermis was inhibited by > 50%, plasma sodium and potassium concentrations were respectively reduced by similar to 20% and similar to 50%, and asystolic cardiac arrest resulted in death. Because the skin is critical in maintaining amphibian homeostasis, disruption to cutaneous function may be the mechanism by which Bd produces morbidity and mortality across a wide range of phylogenetically distant amphibian taxa.