Birth weight and risk of cancer
Birth weight and risk of cancer
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DOI：
10.1002/cncr.22773
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发表时间：
2007-07-15
期刊：
影响因子：
6.2
通讯作者：
Melbye, Mads
中科院分区：
文献类型：
--
作者：
Ahlgren, Martin;Wohlfahrt, Jan;Melbye, Mads
背景。众所周知，产前生物学过程对于某些儿童癌症的发生很重要，但对其对成人癌症风险的影响却知之甚少。高出生体重与乳腺癌风险相关，而对其他特定癌症和所有癌症的研究尚无定论。方法。作者建立了一个由 1936 年至 1975 年间出生的超过 200,000 名男性和女性组成的队列。出生体重来自学校健康记录和丹麦癌症登记处有关癌症的信息。随访时间为1968年4月1日至2003年12月31日。在6,975,553人年的随访期间，总共诊断出12,540例原发性浸润癌。结果。对特定部位癌症的分析表明，大多数癌症与出生体重呈正线性相关。研究发现，胰腺癌和膀胱癌与出生体重呈负相关，而胰腺癌和膀胱癌则偏离正线性关联，具有统计学显着性，而睾丸癌则呈 V 形关联。排除这 3 个例外，各个癌症部位的趋势并无异质性，总体趋势是出生体重每增加 1000 克，相对风险为 1.07（95% 置信区间，1.03-1.11）。这种趋势在男性和女性以及所有年龄组中都是相同的。结论。出生体重每增加 1000 克，癌症风险就会增加 7%。很少有癌症与出生体重呈非线性相关，睾丸癌被发现与出生体重呈负相关。作者假设，出生体重与不同部位癌症之间关联背后的生物学解释应该在共同途径中寻找。
BACKGROUND. it is well established that prenatal biologic processes are important for the development of some childhood cancers, whereas less is known regarding their influence on adult cancer risk. High birth weight has been associated with risk of breast cancer, whereas studies of other specific cancers and all cancers together have been less conclusive.METHODS. The authors established a cohort of more than 200,000 men and women who were born between 1936 and 1975. Birth weights were obtained from school health records and information concerning cancer from the Danish Cancer Registry. Follow-up was performed between April 1, 1968 and December 31, 2003. During 6,975,553 person-years of follow-up, a total of 12,540 primary invasive cancers were diagnosed.RESULTS. Analyses of site-specific cancers revealed that the majority of cancers had a positive linear association with birth weight. Departures from a positive linear association were found to be statistically significant for cancers of the pancreas and bladder, which demonstrated a V-shaped association, and testicular cancer, which demonstrated an inverse association with birth weight. Excluding these 3 exceptions, the trends for the individual cancer sites were not heterogeneous, and the overall trend was a relative risk of 1.07 (95% confidence interval, 1.03-1.11) per 1000-g increase in birth weight. This trend was the same in men and women and in all age groups.CONCLUSIONS. A 7% increase in cancer risk was observed per 1000-g increase in birth weight. Few cancers demonstrated a nonlinear association with birth weight, and testicular cancer was found to be negatively associated with birth weight. The authors hypothesized that the biologic explanation behind the association between birth weight and cancer at different sites should be sought in a common pathway.