Gradients in Planarian Regeneration and Homeostasis
Gradients in Planarian Regeneration and Homeostasis
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DOI：
10.1101/cshperspect.a000505
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发表时间：
2010-01-01
影响因子：
7.2
通讯作者：
Salo, Emili
中科院分区：
文献类型：
--
作者：
Adell, Teresa;Cebria, Francesc;Salo, Emili
Planarian再生是梯度概念发展的第一个模型之一。在形态学研究的基础上，分析了不同部位的真涡虫碎片的再生率、异形体的产生以及组织移植实验。H. Morgan（1901）和C. M Child（1911）假设了不同种类的梯度负责这些高度可塑性动物的再生过程。然而，经过世纪的研究，形态发生素在真涡虫再生中的作用尚未得到证实。这种情况可能很快就会改变，因为涡虫基因组的测序和通过RNA干扰（RNAi）进行基因功能分析的可能性已经导致了骨形态发生蛋白（BMP），Wnt和成纤维细胞生长因子（FGF）途径的分离，这些途径控制着涡虫再生和体内平衡过程中的模式和轴向极性。在这里，我们讨论这些分子的行动是否可以基于形态发生梯度。
Planarian regeneration was one of the first models in which the gradient concept was developed. Morphological studies based on the analysis of the regeneration rates of planarian fragments from different body regions, the generation of heteromorphoses, and experiments of tissue transplantation led T. H. Morgan ( 1901) and C. M Child ( 1911) to postulate different kinds of gradients responsible for the regenerative process in these highly plastic animals. However, after a century of research, the role of morphogens in planarian regeneration has yet to be demonstrated. This may change soon, as the sequencing of the planarian genome and the possibility of performing gene functional analysis by RNA interference (RNAi) have led to the isolation of elements of the bone morphogenetic protein (BMP), Wnt, and fibroblast growth factor (FGF) pathways that control patterning and axial polarity during planarian regeneration and homeostasis. Here, we discuss whether the actions of these molecules could be based on morphogenetic gradients.