Is there a need to identify new anti-emetic drugs?
Is there a need to identify new anti-emetic drugs?
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DOI：
10.1016/j.ddstr.2007.09.002
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Horn, Charles C
中科院分区：
文献类型：
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作者：
Horn, Charles C
恶心和呕吐会出现在许多疾病的情况下，并作为许多药物治疗的副作用，包括在手术中使用镇痛剂和麻醉，在癌症治疗中使用化疗。目前的止吐药物只能缓解某些来源的呕吐，对控制恶心的益处有限。阐明产生恶心的前脑通路和控制呕吐的脑干回路是开发有效的普遍抗恶心和抗呕吐治疗的重要障碍。
Nausea and vomiting occur in a large number of disease conditions and as side effects of many drug treatments, including use of analgesics and anesthesia in surgery and chemotherapy in cancer treatment. Current anti-emetics provide relief from only some sources of vomiting, with more limited benefits for the control of nausea. Elucidation of forebrain pathways that generate nausea and brainstem circuitry controlling emesis are significant obstacles for the development of effective universal anti-nausea and anti-emetic treatments.