Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS)
Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS)
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DOI：
10.1210/jc.2012-3698
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发表时间：
2013-03-01
影响因子：
5.8
通讯作者：
Escobar-Morreale, Hector F.
中科院分区：
文献类型：
--
作者：
Borruel, Susana;Fernandez-Duran, Elena;Escobar-Morreale, Hector F.
背景：两性异形表明雄激素在体内脂肪分布中的作用。多囊卵巢综合征（PCOS）是一种雄激素过多的疾病，常表现为腹部肥胖和内脏脂肪过多。目的：我们假设PCOS患者的男性化体脂分布有利于脂肪沉积在内脏和器官特异性脂肪组织库中。设计：这是一项病例对照研究。设置：该研究在一家学术医院进行。参与者：PCOS患者（n = 55）、无雄激素过多的女性（n = 25）和体重指数相似的男性（n = 26）参与了研究。干预措施：没有干预措施。超声测量脂肪组织库，包括皮下脂肪（最小值和最大值）、腹膜前、腹腔内、肠系膜、心外膜和肾周脂肪厚度，并使用体脂监测器估计总体脂量。与对照组女性相比，男性和PCOS患者的全身脂肪总量增加。与对照组女性相比，男性的腹腔内脂肪组织厚度增加，PCOS女性的ip和肠系膜脂肪厚度显示中间值也高于对照组女性，心外膜脂肪厚度接近达到统计学显著性。与对照女性相比，患有多囊卵巢综合症的女性还显示出最小皮下脂肪厚度增加。肥胖增加了所有的3组subjects.Conclusions中的脂肪组织depots的厚度：PCOS的妇女有较高的全球肥胖和内脏脂肪组织的数量增加与对照组相比，妇女，特别是在IP和肠系膜depots。（临床内分泌代谢杂志98：1254-1263，2013）
Context: Sexual dimorphism suggests a role for androgens in body fat distribution. Women with polycystic ovary syndrome (PCOS), a mainly androgen excess disorder, often present with abdominal obesity and visceral adiposity.Objective: We hypothesized that women with PCOS have a masculinized body fat distribution favoring the deposition of fat in visceral and organ-specific adipose tissue depots.Design: This was a case-control study.Setting: The study was conducted at an academic hospital.Participants: Women with PCOS (n = 55), women without androgen excess (n = 25), and men (n = 26) presenting with similar body mass index participated in the study.Interventions: There were no interventions.Main Outcome Measures: Ultrasound measurements of adipose tissue depots including sc (minimum and maximum), preperitoneal, ip, mesenteric, epicardial, and perirenal fat thickness were obtained and total body fat mass was estimated using a body fat monitor.Results: Men and patients with PCOS had increased amounts of total body fat compared with control women. Men had increased thickness of intraabdominal adipose tissue depots compared with the control women, with the women with PCOS showing intermediate values that were also higher than those of control women in the case of ip and mesenteric fat thickness and was close to reaching statistical significance in the case of epicardial fat thickness. Women with PCOS also showed increased minimum sc fat thickness compared with the control women. Obesity increased the thickness of all of the adipose tissue depots in the 3 groups of subjects.Conclusions: Women with PCOS have higher global adiposity and increased amounts of visceral adipose tissue compared with control women, especially in the ip and mesenteric depots. (J Clin Endocrinol Metab 98: 1254-1263, 2013)