Microdermabrasion as a novel tool to enhance drug delivery via the skin: An animal study
Microdermabrasion as a novel tool to enhance drug delivery via the skin: An animal study
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DOI：
10.1111/j.1524-4725.2006.32224.x
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发表时间：
2006-08-01
影响因子：
2.4
通讯作者：
Fang, Jia-You
中科院分区：
文献类型：
--
作者：
Lee, Woan-Ruoh;Tsai, Ren-Yeu;Fang, Jia-You
微晶磨皮术是一种广泛进行的皮肤更新程序。目的研究微晶磨削术对亲水性和亲脂性药物经皮渗透的影响，为微晶磨削术治疗皮肤病提供实验依据。采用离体猪皮给药和裸鼠局部给药两种方法观察微晶磨削术的效果。在这项研究中使用的真空压力（15-25厘米汞柱）远低于用于治疗purposes.Results的5-FU渗透microdermabrulation治疗的皮肤是8- 24倍高于完整的皮肤，并依赖于治疗压力和持续时间的差异。15 cmHg的强度持续10秒显示出通过皮肤的5-FU递送的最大增强。与5-FU的结果相反，微晶磨皮减少了局部应用的氯倍他索的皮肤渗透和沉积。氯倍他索从溶媒到SC的分配效应可能主导了该结果。微晶磨皮也增强了亲水性5-氨基乙酰丙酸（ALA）的皮肤递送。激光共聚焦扫描显微镜（CLSM）显示，微晶磨皮术可促进亲水性分子的皮肤渗透，在表皮和真皮上层可见ALA转化原卟啉（PpIX）的红色荧光。
BACKGROUND Microdermabrasion is a widely performed skin rejuvenation procedure. It can partly ablate and homogenize the stratum corneum (SC) layers.OBJECTIVE The effect of microdermabrasion treatment on the skin permeation of hydrophilic and lipophilic drugs was examined in this study.METHODS 5-Fluorouracil (5-FU) and clobetasol 17-propionate were used as the hydrophilic and lipophilic permeants, respectively. In vitro skin delivery using porcine skin and in vivo topical application employing nude mouse as the animal model were both used to examine the effect of microdermabrasion. The vacuum pressures used in this study (15-25 cmHg) were much lower than those used for therapeutic purposes.RESULTS The 5-FU permeation across microdermabrasion-treated skin was 8- to 24-fold higher than that across intact skin and depended on differences in treatment pressure and duration. An intensity of 15 cmHg for 10 seconds showed the greatest enhancement of 5-FU delivery via the skin. In contrast to the results for 5-FU, microdermabrasion reduced the skin permeation and deposition of topically applied clobetasol. The partitioning effect of clobetasol from the vehicle to the SC may have predominated this result. Microdermabrasion also enhanced the skin delivery of the hydrophilic 5-aminolevulinic acid (ALA). Confocal laser scanning microscopy (CLSM) of microdermabrasion-treated skin revealed intense red fluorescence of ALA-transformed protoporphyrin (PpIX) within the epidermis and upper dermis.CONCLUSIONS Microdermabrasion can improve the skin permeation of hydrophilic molecules.