Prospective Longitudinal Substance Use Patterns in Patients Preparing for Hepatitis C Treatment.
Prospective Longitudinal Substance Use Patterns in Patients Preparing for Hepatitis C Treatment.
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DOI：
10.1080/15504263.2017.1380246
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发表时间：
2018-01
影响因子：
2.2
通讯作者：
Hong BA
中科院分区：
文献类型：
--
作者：
North CS;Pollio DE;Sims OT;Jain MK;Hong BA
本研究前瞻性地研究了154例准备接受丙型肝炎（HCV）治疗的患者在18个月内酒精、药物和吸烟的独立过程与功能、消极应对和生活质量满意度的关系，这些数据来自一项准备接受HCV治疗的患者的多家庭小组心理教育的随机对照试验。研究对象为持续戒烟、持续使用药物或在进入研究后实现戒烟的HCV患者，研究结果包括HCV背景下的功能、消极应对和生活质量满意度。在两个主要大学医学中心和退伍军人事务部医学中心的门诊招募的309名考虑治疗HCV的患者中，有154名完成了基线，6个月和18个月的评估。评估包括结构化诊断访谈;调查功能、应对和生活质量满意度的问卷;医疗记录审查;以及滥用药物的尿检。对于这些分析，物质使用模式被确定为持续戒断、持续使用以及进入研究后实现戒酒、吸毒和吸烟。在研究过程中，整个样本在所有这三个结果方面都得到了改善。酒精，药物和吸烟的过程中预测HCV相关的功能，消极的应对，并在18个月的生活质量结果的满意度。这些物质的三种特定的物质使用模式（持续禁欲，持续使用和进入研究后禁欲的实现）与功能，消极应对和生活质量满意度相关的结果存在差异，不仅在物质类型内，而且在物质类型之间随时间推移的轨迹。这项研究的发现，不同的物质与不同的临床结果表明，需要在概念上解开不同类型的物质在管理HCV。未来的研究需要进一步研究这些物质的临床效用，并进一步研究这些物质的不同使用量的影响。
This study prospectively examined the independent courses of alcohol, drugs, and smoking over 18 months in 154 patients preparing for hepatitis C (HCV) treatment in relation to functioning, negative coping, and satisfaction with quality of life, in data collected from a randomized controlled trial of multiple-family group psychoeducation for patients preparing for HCV treatment. Patients with HCV who had consistent abstinence, consistent use, or achievement of abstinence after study entry were examined for outcomes pertaining to functioning in the context of HCV, negative coping, and satisfaction with quality of life. Of 309 patients considering treatment for HCV recruited from outpatient clinics at two major university medical centers and a Veterans Affairs medical center for a randomized controlled trial of a psychoeducation intervention, 154 completed baseline, 6-month, and 18-month assessments. The assessments included structured diagnostic interviews; questionnaires examining functioning, coping, and satisfaction with quality of life; medical record review; and urine testing for substances of abuse. For these analyses, substance use patterns were determined as consistent abstinence, consistent use, and achieving abstinence after study entry, for alcohol and drug use and smoking. The entire sample generally improved in all of these three outcomes over the course of the study. The course of alcohol, drugs, and smoking predicted HCV-related functioning, negative coping, and satisfaction with quality of life outcomes over 18 months. Three specific patterns of substance use (consistent abstinence, consistent use, and achievement of abstinence after study entry) of these substances diverged in association with outcomes related to functioning, negative coping, and satisfaction with quality of life, not only across trajectories over time within substance types but also between types of substances. This study’s finding that different substances were associated with distinct clinical outcomes suggests the need to conceptually unbundle different types of substances in managing HCV. Future research is needed to examine the clinical utility of further unbundling of these substances and also to further investigate effects of various amounts of use of these substances.
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DOI：
10.1002/hep.27422
发表时间：
2015-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Boscarino JA;Lu M;Moorman AC;Gordon SC;Rupp LB;Spradling PR;Teshale EH;Schmidt MA;Vijayadeva V;Holmberg SD;Chronic Hepatitis Cohort Study (CHeCS) Investigators
通讯作者：
Chronic Hepatitis Cohort Study (CHeCS) Investigators
影响因子：
5.5
作者：
Osna NA;Ganesan M;Kharbanda KK
通讯作者：
Kharbanda KK
烟草使用会促进 HCV 诱导的 miR-122 劫持和肝癌发生吗？
影响因子：
4.7
作者：
Zhao, Lijun;Li, Farong;Taylor, Ethan Will
通讯作者：
Taylor, Ethan Will
影响因子：
1.6
作者：
Jeng, Jen-Eing;Tsai, Huey-Ru;Chang, Jan-Gowth
通讯作者：
Chang, Jan-Gowth
影响因子：
6.7
作者：
Basseri, Benjamin;Yamini, David;Poordad, Fred
通讯作者：
Poordad, Fred