Noninvasive imaging of prefrontal activation during attention-demanding tasks performed while walking using a wearable optical topography system
Noninvasive imaging of prefrontal activation during attention-demanding tasks performed while walking using a wearable optical topography system
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DOI：
10.1117/1.3462996
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发表时间：
2010-07-01
影响因子：
3.5
通讯作者：
Kubota, Kisou
中科院分区：
文献类型：
--
作者：
Atsumori, Hirokazu;Kiguchi, Masashi;Kubota, Kisou
基于近红外光谱的光学地形图(OT)是一种非侵入性的技术，用于描绘人类大脑皮层中氧合和脱氧血红蛋白(分别为氧合和脱氧-Hb)的相对浓度变化。在我们之前的研究中，我们开发了一种覆盖整个前额的小型、轻型可穿戴光学地形图(WOT)系统，用于监测前额叶的激活情况。在本研究中，我们检验了WOT系统是否适用于行走时的OT测量，这是传统OT系统难以实现的。我们进行OT测量，同时受试者执行一项注意力要求高的(AD)任务，即在走路时平衡一个小卡片上的乒乓球。测得的氧合和脱氧-Hb相对浓度变化的时间历程和功率谱表明，与任务相关的变化相比，氧合和脱氧-Hb信号的阶跃相关变化可以忽略不计。对OXY-Hb信号与任务相关的变化的统计分析表明，在AD任务中，背外侧前额叶皮质和吻侧前额叶区域显著激活。这些结果表明，我们的WOT系统功能成像技术适用于步行时的OT测量，并将成为评估自然环境中大脑激活的有力工具。(C)2010年光学仪器工程师学会。[DOI：10.1117/1.3462996]
Optical topography (OT) based on near-infrared spectroscopy is a noninvasive technique for mapping the relative concentration changes in oxygenated and deoxygenated hemoglobin (oxy- and deoxy-Hb, respectively) in the human cerebral cortex. In our previous study, we developed a small and light wearable optical topography (WOT) system that covers the entire forehead for monitoring prefrontal activation. In the present study, we examine whether the WOT system is applicable to OT measurement while walking, which has been difficult with conventional OT systems. We conduct OT measurements while subjects perform an attention-demanding (AD) task of balancing a ping-pong ball on a small card while walking. The measured time course and power spectra of the relative concentration changes in oxy-and deoxy-Hb show that the step-related changes in the oxy- and deoxy-Hb signals are negligible compared to the task-related changes. Statistical assessment of the task-related changes in the oxy-Hb signals show that the dorsolateral prefrontal cortex and rostral prefrontal area are significantly activated during the AD task. These results suggest that our functional imaging technique with the WOT system is applicable to OT measurement while walking, and will be a powerful tool for evaluating brain activation in a natural environment. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3462996]