Mechanochemical approach for the capping of mixed core CdS/ZnS nanocrystals: Elimination of cadmium toxicity
Mechanochemical approach for the capping of mixed core CdS/ZnS nanocrystals: Elimination of cadmium toxicity
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DOI：
10.1016/j.jcis.2016.09.033
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发表时间：
2017-01-15
影响因子：
9.9
通讯作者：
Psotka, Miroslav
中科院分区：
文献类型：
--
作者：
Bujnakova, Zdenka;Balaz, Matej;Psotka, Miroslav
本文报道了用湿法机械力化学法对硫化镉和硫化镉/硫化锌量子点纳米晶进行包覆的方法。以L-半胱氨酸和聚乙烯吡咯烷酮为封闭剂。在L-半胱氨酸存在下，硫化镉/硫化锌纳米晶对镉的溶解几乎为零。此外，制备的硫化镉和硫化镉/硫化锌半胱氨酸纳米悬浮液的粒径分布呈单峰分布，具有很好的稳定性，Zeta电位测量进一步支持了这一点。傅立叶变换红外光谱(FTIR)和核磁共振光谱(核磁共振)表明半胱氨酸成功嵌入到纳米晶结构中。此外，对半胱氨酸纳米悬浮液的光学性质进行了测试，结果表明，半胱氨酸纳米悬浮液具有良好的荧光性能。另一方面，PVP不是目前体系的一种非常合适的封顶剂。在这种情况下，镉(II)的释放比L-半胱氨酸封顶的样品高。该纳米悬浮液被成功地用于选定的癌细胞系的体外研究。利用荧光显微镜，证明了纳米晶进入细胞，它们可以作为生物医学应用的显像剂。(C)爱思唯尔公司出版的2016年。
The wet mechanochemical procedure for the capping of the CdS and CdS/ZnS quantum dot nanocrystals is reported. L-cysteine and polyvinylpyrrolidone (PVP) were used as capping agents. When using L-cysteine, the dissolution of cadmium(II) was almost none for CdS/ZnS nanocrystals. Moreover, prepared CdS- and CdS/ZnS-cysteine nanosuspensions exhibited unimodal particle size distributions with very good stability, which was further supported by the zeta potential measurements. The Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy showed the successful embedment of cysteine into the structure of the nanocrystals. Additionally, the optical properties were examined, and the results showed that the cysteine nanosuspension has promising fluorescence properties. On the other hand, PVP was not determined to be a very suitable capping agent for the present system. In this case, the release of cadmium(II) was higher in comparison to the L-cysteine capped samples. The nanosuspensions were successfully used for in vitro studies on selected cancer cell lines. Using fluorescence microscopy, it was evidenced that the nanocrystals enter the cell and that they can serve as imaging agents in biomedical applications. (C) 2016 Published by Elsevier Inc.