Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease.
Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease.
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表面脱乙酰甲壳素纳米纤维用磺丁基醚 β-环糊精凝胶增强，负载泼尼松龙作为炎症性肠病的潜在疗法。
DOI：
10.1016/j.carbpol.2017.07.028
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发表时间：
2017
影响因子：
11.2
通讯作者：
Hirayama F.
中科院分区：
文献类型：
--
作者：
Tabuchi R;Anraku M;Iohara D;Ishiguro T;Ifuku S;Nagae T;Uekama K;Okazaki S;Takeshita K;Otagiri M;Hirayama F.
以表面脱乙酰甲壳素纳米纤维（SDACNFs）为载体，磺丁基醚-β-环糊精（SBE-β-CD）为增强剂，制备了一种结肠炎治疗药物泼尼松龙（PD）的控释载体。在pH 1.2和6.8下，PD从凝胶中缓慢释放。PD从NFs-CD凝胶中的体外缓慢释放反映在大鼠口服给药后药物的体内吸收中。这些结果表明，由SDACNF和SBE-β-CD的混合物组成的简单凝胶具有用于PD控制释放的潜力。我们还评估了含有PD的NFs-CD凝胶对葡聚糖硫酸钠（DSS）诱导的结肠炎模型小鼠的治疗作用。从DSS治疗开始以3天的间隔施用NFs-CD凝胶不仅导致结肠炎症状的显著改善，而且导致结肠组织的组织病理学变化的显著改善。此外，NFs-CD凝胶对结肠炎的治疗效果可归因于中性粒细胞浸润水平的降低和氧化应激的发展。含有PD的NFs-CD凝胶的这些功效特征表明，其不仅具有用于治疗结肠炎的潜力，而且具有用于治疗与炎症和氧化损伤相关的各种其他病症的潜力。
Surface-deacetylated chitin nanofibers (SDACNFs) reinforced with a sulfobutyl ether β-cyclodextrin (SBE-β-CD) (NFs-CDs) gel were developed to obtain a controlled release carrier of prednisolone (PD) for the treatment of colitis. PD was released slowly from the gel at both pH 1.2 and 6.8. Thein vitroslow release of PD from the NFs-CDs gel was reflected in thein vivoabsorption of the drug after oral administration to rats. These results suggest that a simple gel composed of a mixture of SDACNFs and SBE-β-CD has the potential for use in the controlled release of PD. We also evaluated the therapeutic effects of the NFs-CDs gel containing PD on dextran sulfate sodium (DSS)-induced colitis model mice. The administration of the NFs-CDs gel at intervals of 3 days from the beginning of the DSS treatment resulted in a significant improvement, not only in colitis symptoms but also histopathological changes in colon tissue. In addition, the therapeutic effects of the NFs-CDs gel on colitis can be attributed to decreased levels of neutrophil infiltration and the development of oxidative stress. These efficacy profiles of the NFs-CDs gel containing PD suggest that it has the potential for use in the treatment of, not only colitis, but also a variety of other disorders associated with inflammation and oxidative injuries.