CONCENTRATION OF ONDANSETRON IN CEREBROSPINAL-FLUID FOLLOWING ORAL DOSING IN VOLUNTEERS
CONCENTRATION OF ONDANSETRON IN CEREBROSPINAL-FLUID FOLLOWING ORAL DOSING IN VOLUNTEERS
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DOI：
10.1007/bf02247730
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发表时间：
1992-12-01
影响因子：
3.4
通讯作者：
WHELAN, P
中科院分区：
文献类型：
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作者：
SIMPSON, KH;MURPHY, P;WHELAN, P
本研究测定了6名志愿者口服恩丹西酮至稳态后血浆和脑脊液（CSF）中的浓度。昂丹司琼浓度范围为39.5 - 147 ng ml-1的血浆和2.6-15.4 ng ml-1的CSF。血药浓度与脑脊液浓度呈良好的相关性（r = 0.89，p = 0.0 17）。在所有情况下，CSF浓度均小于血浆浓度的15%，表明昂丹司琼穿透血脑屏障的速率较低。
This study measured the concentrations of ondansetron in plasma and cerebrospinal fluid (CSF) in six volunteers after oral dosing to steady state. Ondansetron concentrations ranged from 39.5 147 ng ml-1 in plasma and from 2.6-15.4 ng ml-1 in CSF. There was good correlation between plasma and CSF concentrations (r = 0.89, p = 0.0 1 7). CSF concentrations were less than 15% of plasma concentrations in all cases, indicating that the rate of penetration of the blood brain barrier by ondansetron is low.