Post-transcriptional pseudouridylation in mRNA as well as in some major types of noncoding RNAs.
Post-transcriptional pseudouridylation in mRNA as well as in some major types of noncoding RNAs.
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DOI：
10.1016/j.bbagrm.2018.11.002
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Yu YT
中科院分区：
文献类型：
--
作者：
Adachi H;De Zoysa MD;Yu YT
假尿苷化是一种转录后异构化反应，其将尿苷转化为RNA链内的假尿苷（pseudouridine，pseudouridine）。它具有不同于尿苷和任何其他已知核苷酸的化学性质。迄今为止积累的实验数据表明，RNA存在于许多不同类型的RNA中，包括编码和非编码RNA。它特别集中在rRNA和剪接体snRNA中，分别在蛋白质翻译和前mRNA剪接中起重要作用。在mRNA中也发现了它，但它在那里的功能基本上仍然未知。本文主要从rRNA、snRNA和mRNA三个方面综述了RNA假尿苷化的机制和功能。我们还讨论了方法，这已经发展到检测RNA中的RNA。
Pseudouridylation is a post-transcriptional isomerization reaction that converts a uridine to a pseudouridine (Ψ) within an RNA chain. Ψ has chemical properties that are distinct from that of uridine and any other known nucleotides. Experimental data accumulated thus far have indicated that Ψ is present in many different types of RNAs, including coding and noncoding RNAs. Ψ is particularly concentrated in rRNA and spliceosomal snRNAs, and plays an important role in protein translation and pre-mRNA splicing, respectively. Ψ has also been found in mRNA, but its function there remains essentially unknown. In this review, we discuss the mechanisms and functions of RNA pseudouridylation, focusing on rRNA, snRNA and mRNA. We also discuss the methods, which have been developed to detect Ψs in RNAs.
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影响因子：
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作者：
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通讯作者：
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