In Situ Quantitative Graphene-Based Surface-Enhanced Raman Spectroscopy
In Situ Quantitative Graphene-Based Surface-Enhanced Raman Spectroscopy
复制标题
基于石墨烯的原位定量表面增强拉曼光谱
DOI：
10.1002/smtd.201700126
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发表时间：
2017-06-12
期刊：
影响因子：
12.4
通讯作者：
Zhang, Jin
中科院分区：
文献类型：
--
作者：
Tian, Huihui;Zhang, Na;Zhang, Jin
超高灵敏度的定量表面增强拉曼光谱（SERS）将显着促进其在环境监测、食品安全、药物检测等许多领域的实际应用。然而，由于 SERS 光谱的不稳定性和检测到的分子数量的不确定性，仍然存在尚未解决的挑战，特别是在低浓度水平下。在此，报道了一种用于SERS定量的基于石墨烯的柔性透明基底，其中石墨烯的2D单晶性质保证了分子的均匀吸附，有利于分子数量的测定、分子与金属的分离，这确保了拉曼信号的稳定性，以及用于校准SERS强度的内标。探针分子在水溶液中的原位定量可低至10(-8) m的检测限，并可对罗丹明B分子的释放过程进行实时原位监测，模拟实际应用，例如药物的控释。结果为高效率和低成本的实际应用开辟了可靠的 SERS 定量的途径。
Quantitative surface-enhanced Raman spectroscopy (SERS) with ultrahigh sensitivity will significantly promote its practical application in many fields, such as environment monitoring, food safety, and drug detection. However, the challenges that remain unresolved, particularly in the low concentration levels, arise from the instability of the SERS spectra and the uncertainty of the number of detected molecules. Herein, a graphene-based, flexible, and transparent substrate for SERS quantification is reported, wherein the 2D single-crystalline nature of graphene promises the homogeneous adsorption of molecules, facilitating the determination of the number of molecules, the separation of molecules from metal, which ensures the stability of the Raman signals, and an internal standard for the calibration of SERS intensities. The in situ quantification of probe molecules is demonstrated in an aqueous solution down to the detection limit of 10(-8) m, and the real-time, in situ monitoring of the release process of rhodamine B molecules, which mimics practical application, for example, the controlled release of medicine, is shown. The results open up an avenue for reliable SERS quantification for practical applications with high efficiency and low cost.